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FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals

The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagn...

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Autores principales: Kang, Hyo Jung, Yoon, Sujung, Lee, Suji, Choi, Koeul, Seol, Sihwan, Park, Shinwon, Namgung, Eun, Kim, Tammy D., Chung, Yong-An, Kim, Jungyoon, Han, Jung-Soo, Lyoo, In Kyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042218/
https://www.ncbi.nlm.nih.gov/pubmed/32098997
http://dx.doi.org/10.1038/s41598-020-60334-6
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author Kang, Hyo Jung
Yoon, Sujung
Lee, Suji
Choi, Koeul
Seol, Sihwan
Park, Shinwon
Namgung, Eun
Kim, Tammy D.
Chung, Yong-An
Kim, Jungyoon
Han, Jung-Soo
Lyoo, In Kyoon
author_facet Kang, Hyo Jung
Yoon, Sujung
Lee, Suji
Choi, Koeul
Seol, Sihwan
Park, Shinwon
Namgung, Eun
Kim, Tammy D.
Chung, Yong-An
Kim, Jungyoon
Han, Jung-Soo
Lyoo, In Kyoon
author_sort Kang, Hyo Jung
collection PubMed
description The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTSD. Using a translational approach, candidate miRNAs found to alter in expression within the medial prefrontal cortex of FKBP5 knockout mice were selected. Each candidate miRNA was examined in the serum of 48 recently traumatized individuals with PTSD and 47 healthy individuals. Multimodal imaging was also conducted to identify the neural correlates for the expression of candidate exosomal miRNAs in response to trauma exposure. Differential miRNA expression was found according to PTSD diagnosis in two composite marker groups. The differential miRNA expression between the composite marker groups contributed to PTSD symptom severity, which may be explained by differential recruitment of prefrontolimbic activity in brain imaging. The present study reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic markers of PTSD. The corroborative evidence from multiple levels including molecular, brain, and behavioral indicates that these epigenetic biomarkers may serve as complementary measures for the diagnosis and prognosis prediction of PTSD in recently traumatized individuals.
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spelling pubmed-70422182020-03-03 FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals Kang, Hyo Jung Yoon, Sujung Lee, Suji Choi, Koeul Seol, Sihwan Park, Shinwon Namgung, Eun Kim, Tammy D. Chung, Yong-An Kim, Jungyoon Han, Jung-Soo Lyoo, In Kyoon Sci Rep Article The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTSD. Using a translational approach, candidate miRNAs found to alter in expression within the medial prefrontal cortex of FKBP5 knockout mice were selected. Each candidate miRNA was examined in the serum of 48 recently traumatized individuals with PTSD and 47 healthy individuals. Multimodal imaging was also conducted to identify the neural correlates for the expression of candidate exosomal miRNAs in response to trauma exposure. Differential miRNA expression was found according to PTSD diagnosis in two composite marker groups. The differential miRNA expression between the composite marker groups contributed to PTSD symptom severity, which may be explained by differential recruitment of prefrontolimbic activity in brain imaging. The present study reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic markers of PTSD. The corroborative evidence from multiple levels including molecular, brain, and behavioral indicates that these epigenetic biomarkers may serve as complementary measures for the diagnosis and prognosis prediction of PTSD in recently traumatized individuals. Nature Publishing Group UK 2020-02-25 /pmc/articles/PMC7042218/ /pubmed/32098997 http://dx.doi.org/10.1038/s41598-020-60334-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kang, Hyo Jung
Yoon, Sujung
Lee, Suji
Choi, Koeul
Seol, Sihwan
Park, Shinwon
Namgung, Eun
Kim, Tammy D.
Chung, Yong-An
Kim, Jungyoon
Han, Jung-Soo
Lyoo, In Kyoon
FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
title FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
title_full FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
title_fullStr FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
title_full_unstemmed FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
title_short FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
title_sort fkbp5-associated mirna signature as a putative biomarker for ptsd in recently traumatized individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042218/
https://www.ncbi.nlm.nih.gov/pubmed/32098997
http://dx.doi.org/10.1038/s41598-020-60334-6
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