Combination of chemotherapy and PD-1 blockade induces T cell responses to tumor non-mutated neoantigens

Here, we developed an unbiased, functional target-discovery platform to identify immunogenic proteins from primary non-small cell lung cancer (NSCLC) cells that had been induced to apoptosis by cisplatin (CDDP) treatment in vitro, as compared with their live counterparts. Among the multitude of prot...

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Detalles Bibliográficos
Autores principales: Grimaldi, Alessio, Cammarata, Ilenia, Martire, Carmela, Focaccetti, Chiara, Piconese, Silvia, Buccilli, Marta, Mancone, Carmine, Buzzacchino, Federica, Berrios, Julio Rodrigo Giron, D’Alessandris, Nicoletta, Tomao, Silverio, Giangaspero, Felice, Paroli, Marino, Caccavale, Rosalba, Spinelli, Gian Paolo, Girelli, Gabriella, Peruzzi, Giovanna, Nisticò, Paola, Spada, Sheila, Panetta, Mariangela, Letizia Cecere, Fabiana, Visca, Paolo, Facciolo, Francesco, Longo, Flavia, Barnaba, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042341/
https://www.ncbi.nlm.nih.gov/pubmed/32099064
http://dx.doi.org/10.1038/s42003-020-0811-x

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