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Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats
Mitochondrial autophagy is involved in myocardial protection of sevoflurane postconditioning (SPostC) and in diabetic state this protective effect is weakened due to impaired HIF-1 signaling pathway. Previous studies have proved that deferoxamine (DFO) could activate impaired HIF-1α in diabetic stat...
Autores principales: | Yang, Long, Xie, Peng, Wu, Jianjiang, Yu, Jin, Li, Xin, Ma, Haiping, Yu, Tian, Wang, Haiying, Ye, Jianrong, Wang, Jiang, Zheng, Hong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042377/ https://www.ncbi.nlm.nih.gov/pubmed/32140105 http://dx.doi.org/10.3389/fphar.2020.00006 |
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