Decreased expression of LRA4, a key gene involved in rhamnose metabolism, caused up-regulated expression of the genes in this pathway and autophagy in Pichia pastoris

In a previous study, we developed Pichia pastoris GS115m, an engineered strain with decreased expression of one key gene, LRA4, in rhamnose metabolism. P. pastoris GS115m/LacB was subsequently constructed via introducing a β-galactosidase gene, LacB, under the control of rhamnose-inducible P(LRA3) i...

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Detalles Bibliográficos
Autores principales: Jiao, Jian, Wang, Shuai, Tian, Hui, Xu, Xinxin, Zhang, Yuhong, Liu, Bo, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042458/
https://www.ncbi.nlm.nih.gov/pubmed/32100129
http://dx.doi.org/10.1186/s13568-020-00971-2

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