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Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neuro...

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Detalles Bibliográficos
Autores principales: Mohd Sairazi, Nur Shafika, Sirajudeen, K. N. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042511/
https://www.ncbi.nlm.nih.gov/pubmed/32148547
http://dx.doi.org/10.1155/2020/6565396
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author Mohd Sairazi, Nur Shafika
Sirajudeen, K. N. S.
author_facet Mohd Sairazi, Nur Shafika
Sirajudeen, K. N. S.
author_sort Mohd Sairazi, Nur Shafika
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description In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.
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spelling pubmed-70425112020-03-08 Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases Mohd Sairazi, Nur Shafika Sirajudeen, K. N. S. Evid Based Complement Alternat Med Review Article In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases. Hindawi 2020-02-14 /pmc/articles/PMC7042511/ /pubmed/32148547 http://dx.doi.org/10.1155/2020/6565396 Text en Copyright © 2020 Nur Shafika Mohd Sairazi and K. N. S. Sirajudeen. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mohd Sairazi, Nur Shafika
Sirajudeen, K. N. S.
Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
title Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
title_full Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
title_fullStr Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
title_full_unstemmed Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
title_short Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
title_sort natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042511/
https://www.ncbi.nlm.nih.gov/pubmed/32148547
http://dx.doi.org/10.1155/2020/6565396
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