Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra

Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1.5 per million in women. Due to the rarity of the disease, there are a limited number of prospective random...

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Autores principales: Suthar, Krishna H., Kesireddy, Meghana, Sides, Mark, Correa, Amit, Ukudeyva, Aijan, Venkatesan, Rohit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042525/
https://www.ncbi.nlm.nih.gov/pubmed/32110455
http://dx.doi.org/10.1155/2020/7948538
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author Suthar, Krishna H.
Kesireddy, Meghana
Sides, Mark
Correa, Amit
Ukudeyva, Aijan
Venkatesan, Rohit
author_facet Suthar, Krishna H.
Kesireddy, Meghana
Sides, Mark
Correa, Amit
Ukudeyva, Aijan
Venkatesan, Rohit
author_sort Suthar, Krishna H.
collection PubMed
description Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1.5 per million in women. Due to the rarity of the disease, there are a limited number of prospective randomized controlled trials to evaluate the optimal management of locally advanced urethral SCC. Here, we present the case of a 47-year-old man with stage IIIB urethral squamous cell cancer that showed complete clinical and pathologic response to neoadjuvant chemoradiation with only 5-flurouracil after incomplete response to traditional chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP).
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spelling pubmed-70425252020-02-27 Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra Suthar, Krishna H. Kesireddy, Meghana Sides, Mark Correa, Amit Ukudeyva, Aijan Venkatesan, Rohit Case Rep Oncol Med Case Report Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1.5 per million in women. Due to the rarity of the disease, there are a limited number of prospective randomized controlled trials to evaluate the optimal management of locally advanced urethral SCC. Here, we present the case of a 47-year-old man with stage IIIB urethral squamous cell cancer that showed complete clinical and pathologic response to neoadjuvant chemoradiation with only 5-flurouracil after incomplete response to traditional chemotherapy with paclitaxel, ifosfamide, and cisplatin (TIP). Hindawi 2020-02-14 /pmc/articles/PMC7042525/ /pubmed/32110455 http://dx.doi.org/10.1155/2020/7948538 Text en Copyright © 2020 Krishna H. Suthar et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Suthar, Krishna H.
Kesireddy, Meghana
Sides, Mark
Correa, Amit
Ukudeyva, Aijan
Venkatesan, Rohit
Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra
title Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra
title_full Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra
title_fullStr Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra
title_full_unstemmed Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra
title_short Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra
title_sort neoadjuvant radiation with concurrent 5-fu resulting in complete pathologic response in stage iiib squamous cell carcinoma of the urethra
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042525/
https://www.ncbi.nlm.nih.gov/pubmed/32110455
http://dx.doi.org/10.1155/2020/7948538
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