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DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition
OBJECTIVES: To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042540/ https://www.ncbi.nlm.nih.gov/pubmed/32149076 http://dx.doi.org/10.1155/2020/1470868 |
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author | Martínez B., Diana A. Barato Gómez, Paola Andrea Iregui Castro, Carlos Arturo Rosas Pérez, Jaiver E. |
author_facet | Martínez B., Diana A. Barato Gómez, Paola Andrea Iregui Castro, Carlos Arturo Rosas Pérez, Jaiver E. |
author_sort | Martínez B., Diana A. |
collection | PubMed |
description | OBJECTIVES: To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B ( RESULTS: The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10–12 weeks of exposition. In addition, the frequency of histopathological lesions was higher. CONCLUSION: Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed. |
format | Online Article Text |
id | pubmed-7042540 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-70425402020-03-08 DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition Martínez B., Diana A. Barato Gómez, Paola Andrea Iregui Castro, Carlos Arturo Rosas Pérez, Jaiver E. Biomed Res Int Research Article OBJECTIVES: To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. Materials and Methods. Two different experiments were performed. In the first experiment, hamsters' right buccal pouches in group A (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B (n = 10) were painted three times per week with 7,12-dimethylbenzanthracene (DMBA) 0.5%, while pouches of animals in group B ( RESULTS: The time of macroscopic neoplasm development was reduced when DM-DMBA coexposition was employed, finding tumors after 10–12 weeks of exposition. In addition, the frequency of histopathological lesions was higher. CONCLUSION: Immunomodulatory action of dexamethasone may reduce the time of oral squamous cell carcinoma (OSCC) induction and may increase the incidence of neoplasms developed. Hindawi 2020-02-13 /pmc/articles/PMC7042540/ /pubmed/32149076 http://dx.doi.org/10.1155/2020/1470868 Text en Copyright © 2020 Diana A. Martínez B. et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Martínez B., Diana A. Barato Gómez, Paola Andrea Iregui Castro, Carlos Arturo Rosas Pérez, Jaiver E. DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition |
title | DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition |
title_full | DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition |
title_fullStr | DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition |
title_full_unstemmed | DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition |
title_short | DMBA-Induced Oral Carcinoma in Syrian Hamster: Increased Carcinogenic Effect by Dexamethasone Coexposition |
title_sort | dmba-induced oral carcinoma in syrian hamster: increased carcinogenic effect by dexamethasone coexposition |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042540/ https://www.ncbi.nlm.nih.gov/pubmed/32149076 http://dx.doi.org/10.1155/2020/1470868 |
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