Cargando…

Downregulation of MicroRNA-206 Alleviates the Sublethal Oxidative Stress-Induced Premature Senescence and Dysfunction in Mesenchymal Stem Cells via Targeting Alpl

Bone marrow-derived mesenchymal stem cells (MSCs) have shown great promise in tissue engineering and regenerative medicine; however, the regenerative capacity of senescent MSCs is greatly reduced, thus exhibiting limited therapy potential. Previous studies uncovered that microRNA-206 (miR-206) could...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xuan, Yang, Ziying, Meng, Qingyou, Chen, Yueqiu, Shao, Lianbo, Li, Jingjing, Chen, Yihuan, Shen, Zhenya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042556/ https://www.ncbi.nlm.nih.gov/pubmed/32148656 http://dx.doi.org/10.1155/2020/7242836

Ejemplares similares

MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction
por: Ma, Teng, et al.
Publicado: (2018)

The enhanced effect and underlying mechanisms of mesenchymal stem cells with IL-33 overexpression on myocardial infarction
por: Chen, Yueqiu, et al.
Publicado: (2019)

HIF-1α overexpression in mesenchymal stem cell-derived exosomes mediates cardioprotection in myocardial infarction by enhanced angiogenesis
por: Sun, Jiacheng, et al.
Publicado: (2020)

Engineered Exosomes With Ischemic Myocardium‐Targeting Peptide for Targeted Therapy in Myocardial Infarction
por: Wang, Xu, et al.
Publicado: (2018)

Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells
por: Liu, Wenjia, et al.
Publicado: (2018)

Correction: Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells
por: Liu, Wenjia, et al.
Publicado: (2020)

Sublethal Oxidative Stress Induces the Premature Senescence of Human Mesenchymal Stem Cells Derived from Endometrium
por: Burova, Elena, et al.
Publicado: (2013)

MicroRNA-133 overexpression promotes the therapeutic efficacy of mesenchymal stem cells on acute myocardial infarction
por: Chen, Yueqiu, et al.
Publicado: (2017)

Clinical Outcomes by Consolidation of Bone Marrow Stem Cell Therapy and Coronary Artery Bypass Graft in Patients With Heart Failure With Reduced Ejection Fraction: A Meta-analysis
por: Jiang, Yinhao, et al.
Publicado: (2023)

Direct reprogramming of fibroblasts into cardiomyocytes
por: Chen, Yueqiu, et al.
Publicado: (2017)

MicroRNA-206 Downregulation Improves Therapeutic Gene Expression and Motor Function in mdx Mice
por: Bulaklak, Karen, et al.
Publicado: (2018)

Six ALPL gene variants in five children with hypophosphatasia
por: Su, Na, et al.
Publicado: (2021)

The application of umbilical cord‐derived MSCs in cardiovascular diseases
por: Chen, Yueqiu, et al.
Publicado: (2021)

A novel missense mutation in the ALPL gene causes dysfunction of the protein
por: Chen, Bin, et al.
Publicado: (2017)

Downregulation of CCL2 induced by the upregulation of microRNA-206 is associated with the severity of HEV71 encephalitis
por: Zhang, Guangyou, et al.
Publicado: (2017)

Sublethal whole-body irradiation causes progressive premature frailty in mice
por: Fielder, Edward, et al.
Publicado: (2019)

Case Report: Variations in the ALPL Gene in Chinese Patients With Hypophosphatasia
por: Zhang, Qiang, et al.
Publicado: (2021)

Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms
por: Xie, Jingfang, et al.
Publicado: (2023)

GSK3β rephosphorylation rescues ALPL deficiency-induced impairment of odontoblastic differentiation of DPSCs
por: Zhang, Liqiang, et al.
Publicado: (2021)

Downregulation of microRNA-132 indicates progression in hepatocellular carcinoma
por: Zhang, Xin, et al.
Publicado: (2016)

An immunometabolic patch facilitates mesenchymal stromal/stem cell therapy for myocardial infarction through a macrophage‐dependent mechanism
por: Xiao, Weizhang, et al.
Publicado: (2022)

Adult hypophosphatasia with a novel ALPL mutation: Report of an Indian kindred
por: Bhadada, Sanjay K., et al.
Publicado: (2020)

Can we identify individuals with an ALPL variant in adults with persistent hypophosphatasaemia?
por: Tornero, C., et al.
Publicado: (2020)

Genotype–Phenotype Associations in 72 Adults with Suspected ALPL-Associated Hypophosphatasia
por: Jandl, Nico Maximilian, et al.
Publicado: (2020)

ALPL-1 is a target for chimeric antigen receptor therapy in osteosarcoma
por: Mensali, Nadia, et al.
Publicado: (2023)

microRNA-206 is involved in survival of hypoxia preconditioned mesenchymal stem cells through targeting Pim-1 kinase
por: Zhang, You, et al.
Publicado: (2016)

Characterization of Genetic Variants of Uncertain Significance for the ALPL Gene in Patients With Adult Hypophosphatasia
por: Sanabria-de la Torre, Raquel, et al.
Publicado: (2022)

Biochemical algorithm to identify individuals with ALPL variants among subjects with persistent hypophosphatasaemia
por: Tornero, C., et al.
Publicado: (2022)

THU459 Hypophosphatasia With Normal ALPL Gene Test; A Case Report
por: Alkwatli, Kenda, et al.
Publicado: (2023)

MicroRNA-206: a Promising Theranostic Marker
por: Novák, Jan, et al.
Publicado: (2014)

Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy
por: Sai, Xiaoyan, et al.
Publicado: (2020)

Pyridoxine-Responsive Seizures in Infantile Hypophosphatasia and a Novel Homozygous Mutation in ALPL Gene
por: Güzel Nur, Banu, et al.
Publicado: (2016)

The Alkaline Phosphatase (ALPL) Locus Is Associated with B6 Vitamer Levels in CSF and Plasma
por: Olde Loohuis, Loes M., et al.
Publicado: (2018)

Four novel mutations in the ALPL gene in Chinese patients with odonto, childhood, and adult hypophosphatasia
por: Xu, Lijun, et al.
Publicado: (2018)

Phenotypic Profiling in Subjects Heterozygous for 1 of 2 Rare Variants in the Hypophosphatasia Gene (ALPL)
por: Tilden, Daniel R, et al.
Publicado: (2020)

Identification of a novel homozygous variant in the alkaline phosphate (ALPL) gene associated with hypophosphatasia
por: Bisgin, Atil, et al.
Publicado: (2020)

Pain and health-related quality of life in patients with hypophosphatasemia with and without ALPL gene mutations
por: Santurtún, Maite, et al.
Publicado: (2022)

Childhood Hypophosphatasia Associated with a Novel Biallelic ALPL Variant at the TNSALP Dimer Interface
por: Martins, Luciane, et al.
Publicado: (2022)

Evaluation of Circulating Endothelial Progenitor Cells in Abdominal Aortic Aneurysms after Endovascular Aneurysm Repair
por: Wu, Weihua, et al.
Publicado: (2021)

Enhancement of Immunoregulatory Function of Modified Bone Marrow Mesenchymal Stem Cells by Targeting SOCS1
por: Zhang, Xiaoming, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hd9s9o71b7qrq8lqgcj3k2trjl