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Proteomics approach and techniques in identification of reliable biomarkers for diseases

Biomarkers, also called biological markers, are indicators to identify a biological case or situation as well as detecting any presence of biological activities and processes. Proteins are considered as a type of biomarkers based on their characteristics. Therefore, proteomics approach is one of the...

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Autor principal: Alharbi, Raed Abdullah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042613/
https://www.ncbi.nlm.nih.gov/pubmed/32127776
http://dx.doi.org/10.1016/j.sjbs.2020.01.020
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author Alharbi, Raed Abdullah
author_facet Alharbi, Raed Abdullah
author_sort Alharbi, Raed Abdullah
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description Biomarkers, also called biological markers, are indicators to identify a biological case or situation as well as detecting any presence of biological activities and processes. Proteins are considered as a type of biomarkers based on their characteristics. Therefore, proteomics approach is one of the most promising approaches in this field. The purpose of this review is to summarize the use of proteomics approach and techniques to identify proteins as biomarkers for different diseases. This review was obtained by searching in a computerized database. So, different researches and studies that used proteomics approach to identify different biomarkers for different diseases were reviewed. Also, techniques of proteomics that are used to identify proteins as biomarkers were collected. Techniques and methods of proteomics approach are used for the identification of proteins' activities and presence as biomarkers for different types of diseases from different types of samples. There are three essential steps of this approach including: extraction and separation of proteins, identification of proteins, and verification of proteins. Finally, clinical trials for new discovered biomarker or undefined biomarker would be on.
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spelling pubmed-70426132020-03-03 Proteomics approach and techniques in identification of reliable biomarkers for diseases Alharbi, Raed Abdullah Saudi J Biol Sci Article Biomarkers, also called biological markers, are indicators to identify a biological case or situation as well as detecting any presence of biological activities and processes. Proteins are considered as a type of biomarkers based on their characteristics. Therefore, proteomics approach is one of the most promising approaches in this field. The purpose of this review is to summarize the use of proteomics approach and techniques to identify proteins as biomarkers for different diseases. This review was obtained by searching in a computerized database. So, different researches and studies that used proteomics approach to identify different biomarkers for different diseases were reviewed. Also, techniques of proteomics that are used to identify proteins as biomarkers were collected. Techniques and methods of proteomics approach are used for the identification of proteins' activities and presence as biomarkers for different types of diseases from different types of samples. There are three essential steps of this approach including: extraction and separation of proteins, identification of proteins, and verification of proteins. Finally, clinical trials for new discovered biomarker or undefined biomarker would be on. Elsevier 2020-03 2020-01-27 /pmc/articles/PMC7042613/ /pubmed/32127776 http://dx.doi.org/10.1016/j.sjbs.2020.01.020 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Alharbi, Raed Abdullah
Proteomics approach and techniques in identification of reliable biomarkers for diseases
title Proteomics approach and techniques in identification of reliable biomarkers for diseases
title_full Proteomics approach and techniques in identification of reliable biomarkers for diseases
title_fullStr Proteomics approach and techniques in identification of reliable biomarkers for diseases
title_full_unstemmed Proteomics approach and techniques in identification of reliable biomarkers for diseases
title_short Proteomics approach and techniques in identification of reliable biomarkers for diseases
title_sort proteomics approach and techniques in identification of reliable biomarkers for diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042613/
https://www.ncbi.nlm.nih.gov/pubmed/32127776
http://dx.doi.org/10.1016/j.sjbs.2020.01.020
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