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Temporal bone histopathology: Superior semicircular canal dehiscence

OBJECTIVES: To present a histopathological case of a 91‐year‐old woman who was diagnosed with superior semicircular canal dehiscence postmortem. METHODS: The patient was a registered donor with the National Temporal Bone Donor Program at the NIDCD National Temporal Bone, Hearing and Balance Patholog...

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Autores principales: Lin, Brian M., Reinshagen, Katherine, Nadol, Joseph, Quesnel, Alicia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042660/
https://www.ncbi.nlm.nih.gov/pubmed/32128437
http://dx.doi.org/10.1002/lio2.332
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author Lin, Brian M.
Reinshagen, Katherine
Nadol, Joseph
Quesnel, Alicia M.
author_facet Lin, Brian M.
Reinshagen, Katherine
Nadol, Joseph
Quesnel, Alicia M.
author_sort Lin, Brian M.
collection PubMed
description OBJECTIVES: To present a histopathological case of a 91‐year‐old woman who was diagnosed with superior semicircular canal dehiscence postmortem. METHODS: The patient was a registered donor with the National Temporal Bone Donor Program at the NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry. Computed tomography imaging was performed on each temporal bone. The temporal bones were decalcified with ethylenediaminetetracetate and embedded in celloidin, and tissue sections were stained with hematoxylin and eosin. Horizontal sections were taken through the left temporal bone, and vertical sections were taken through the right temporal bone. RESULTS: Histopathological sections taken through the right temporal bone demonstrated no bone between the membranous wall of the superior semicircular canal and the middle fossa dura. There was no histopathological evidence of superior semicircular canal dehiscence in the left temporal bone; however, a small dehiscence would not be identified on horizontal sections. Microcavitations were observed in the common crus of the left temporal bone. CONCLUSION: This reports describes the case of a woman who was diagnosed with superior semicircular canal dehiscence postmortem. The presence of microcavitations in the temporal bone is consistent with osteoclastic activity, which may play a role in the development of superior canal dehiscence.
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spelling pubmed-70426602020-03-03 Temporal bone histopathology: Superior semicircular canal dehiscence Lin, Brian M. Reinshagen, Katherine Nadol, Joseph Quesnel, Alicia M. Laryngoscope Investig Otolaryngol OTOLOGY, NEUROTOLOGY, AND NEUROSCIENCE OBJECTIVES: To present a histopathological case of a 91‐year‐old woman who was diagnosed with superior semicircular canal dehiscence postmortem. METHODS: The patient was a registered donor with the National Temporal Bone Donor Program at the NIDCD National Temporal Bone, Hearing and Balance Pathology Resource Registry. Computed tomography imaging was performed on each temporal bone. The temporal bones were decalcified with ethylenediaminetetracetate and embedded in celloidin, and tissue sections were stained with hematoxylin and eosin. Horizontal sections were taken through the left temporal bone, and vertical sections were taken through the right temporal bone. RESULTS: Histopathological sections taken through the right temporal bone demonstrated no bone between the membranous wall of the superior semicircular canal and the middle fossa dura. There was no histopathological evidence of superior semicircular canal dehiscence in the left temporal bone; however, a small dehiscence would not be identified on horizontal sections. Microcavitations were observed in the common crus of the left temporal bone. CONCLUSION: This reports describes the case of a woman who was diagnosed with superior semicircular canal dehiscence postmortem. The presence of microcavitations in the temporal bone is consistent with osteoclastic activity, which may play a role in the development of superior canal dehiscence. John Wiley & Sons, Inc. 2019-12-11 /pmc/articles/PMC7042660/ /pubmed/32128437 http://dx.doi.org/10.1002/lio2.332 Text en © 2019 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals, Inc. on behalf of The Triological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle OTOLOGY, NEUROTOLOGY, AND NEUROSCIENCE
Lin, Brian M.
Reinshagen, Katherine
Nadol, Joseph
Quesnel, Alicia M.
Temporal bone histopathology: Superior semicircular canal dehiscence
title Temporal bone histopathology: Superior semicircular canal dehiscence
title_full Temporal bone histopathology: Superior semicircular canal dehiscence
title_fullStr Temporal bone histopathology: Superior semicircular canal dehiscence
title_full_unstemmed Temporal bone histopathology: Superior semicircular canal dehiscence
title_short Temporal bone histopathology: Superior semicircular canal dehiscence
title_sort temporal bone histopathology: superior semicircular canal dehiscence
topic OTOLOGY, NEUROTOLOGY, AND NEUROSCIENCE
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042660/
https://www.ncbi.nlm.nih.gov/pubmed/32128437
http://dx.doi.org/10.1002/lio2.332
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