Clinical Effects of the Self-administered Subcutaneous Complement Inhibitor Zilucoplan in Patients With Moderate to Severe Generalized Myasthenia Gravis: Results of a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial

IMPORTANCE: Many patients with generalized myasthenia gravis (gMG) have substantial clinical disability, persistent disease burden, and adverse effects attributable to chronic immunosuppression. Therefore, there is a significant need for targeted, well-tolerated therapies with the potential to impro...

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Detalles Bibliográficos
Autores principales: Howard, James F., Nowak, Richard J., Wolfe, Gil I., Freimer, Miriam L., Vu, Tuan H., Hinton, John L., Benatar, Michael, Duda, Petra W., MacDougall, James E., Farzaneh-Far, Ramin, Kaminski, Henry J., Barohn, Richard, Dimachkie, Mazen, Pasnoor, Mamatha, Farmakidis, Constantine, Liu, Tina, Colgan, Samantha, Benatar, Michael G., Bertorini, Tulio, Pillai, Rekha, Henegar, Robert, Bromberg, Mark, Gibson, Summer, Janecki, Teresa, Freimer, Miriam, Elsheikh, Bakri, Matisak, Paige, Genge, Angela, Guidon, Amanda, David, William, Habib, Ali A., Mathew, Veena, Mozaffar, Tahseen, Hewitt, William, Barnett, Deborah, Sullivan, Patricia, Ho, Doreen, Traub, Rebecca E., Chopra, Manisha, Aly, Radwa, Bayat, Elham, Abu-Rub, Mohammad, Khan, Shaida, Lange, Dale, Holzberg, Shara, Khatri, Bhupendra, Lindman, Emily, Olapo, Tayo, Sershon, Lisa M., Lisak, Robert P., Bernitsas, Evanthia, Jia, Kelly, Malik, Rabia, Lewis-Collins, Tiffany D., Nicolle, Michael, Sharma, Aditi, Roy, Bhaskar, Nye, Joan, Pulley, Michael, Berger, Alan, Shabbir, Yasmeen, Sachdev, Amit, Patterson, Kimberly, Siddiqi, Zaeem, Sivak, Mark, Bratton, Joan, Small, George, Kohli, Anem, Fetter, Mary, Vu, Tuan, Lam, Lucy, Harvey, Brittany, Silvestri, Nicholas, Patrick, Kara, Zakalik, Karen, MacDougall, James, Pontius, Angela, Hoarty, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2020
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042797/
https://www.ncbi.nlm.nih.gov/pubmed/32065623
http://dx.doi.org/10.1001/jamaneurol.2019.5125

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