Cargando…

Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease

IMPORTANCE: Better understanding is needed of the degree to which individuals tolerate Alzheimer disease (AD)–like pathological tau with respect to brain structure (brain resilience) and cognition (cognitive resilience). OBJECTIVE: To examine the demographic (age, sex, and educational level), geneti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ossenkoppele, Rik, Lyoo, Chul Hyoung, Jester-Broms, Jonas, Sudre, Carole H., Cho, Hanna, Ryu, Young Hoon, Choi, Jae Yong, Smith, Ruben, Strandberg, Olof, Palmqvist, Sebastian, Kramer, Joel, Boxer, Adam L., Gorno-Tempini, Maria L., Miller, Bruce L., La Joie, Renaud, Rabinovici, Gil D., Hansson, Oskar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Medical Association 2020
Materias:	Original Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042808/ https://www.ncbi.nlm.nih.gov/pubmed/32091549 http://dx.doi.org/10.1001/jamaneurol.2019.5154

Ejemplares similares

Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer’s disease
por: Ossenkoppele, Rik, et al.
Publicado: (2020)

Determinants of cognitive and brain resilience to tau pathology: a longitudinal analysis
por: Bocancea, Diana I, et al.
Publicado: (2023)

The impact of demographic, clinical, genetic, and imaging variables on tau PET status
por: Ossenkoppele, Rik, et al.
Publicado: (2020)

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging
por: Ossenkoppele, Rik, et al.
Publicado: (2021)

A multicenter comparison of [(18)F]flortaucipir, [(18)F]RO948, and [(18)F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis
por: Leuzy, Antoine, et al.
Publicado: (2021)

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
por: Ossenkoppele, Rik, et al.
Publicado: (2019)

Amyloid and tau accumulate across distinct spatial networks and are differentially associated with brain connectivity
por: Pereira, Joana B, et al.
Publicado: (2019)

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study
por: Mattsson, Niklas, et al.
Publicado: (2018)

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease
por: Mattsson-Carlgren, Niklas, et al.
Publicado: (2020)

The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects
por: Smith, Ruben, et al.
Publicado: (2020)

Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain
por: Ossenkoppele, Rik, et al.
Publicado: (2019)

Phospho-tau with subthreshold tau-PET predicts increased tau accumulation rates in amyloid-positive individuals
por: Groot, Colin, et al.
Publicado: (2022)

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease
por: Franzmeier, Nicolai, et al.
Publicado: (2020)

Tau PET correlates with different Alzheimer’s disease‐related features compared to CSF and plasma p‐tau biomarkers
por: Ossenkoppele, Rik, et al.
Publicado: (2021)

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease
por: Pichet Binette, Alexa, et al.
Publicado: (2022)

Tau-related grey matter network breakdown across the Alzheimer’s disease continuum
por: Pelkmans, Wiesje, et al.
Publicado: (2021)

Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration
por: Mattsson-Carlgren, Niklas, et al.
Publicado: (2022)

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease
por: Iaccarino, Leonardo, et al.
Publicado: (2017)

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders
por: Leuzy, Antoine, et al.
Publicado: (2020)

Higher levels of myelin are associated with higher resistance against tau pathology in Alzheimer’s disease
por: Rubinski, Anna, et al.
Publicado: (2022)

Medial temporal lobe connectivity and its associations with cognition in early Alzheimer’s disease
por: Berron, David, et al.
Publicado: (2020)

Corrigendum to: Medial temporal lobe connectivity and its associations with cognition in early Alzheimer’s disease
por: Berron, David, et al.
Publicado: (2021)

Associations of Plasma Phospho-Tau217 Levels With Tau Positron Emission Tomography in Early Alzheimer Disease
por: Janelidze, Shorena, et al.
Publicado: (2020)

Biomarker-Based Prediction of Longitudinal Tau Positron Emission Tomography in Alzheimer Disease
por: Leuzy, Antoine, et al.
Publicado: (2021)

Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease
por: Leuzy, Antoine, et al.
Publicado: (2023)

Axonal degeneration and amyloid pathology predict cognitive decline beyond cortical atrophy
por: Svenningsson, Anna Linnéa, et al.
Publicado: (2022)

Patient-centered connectivity-based prediction of tau pathology spread in Alzheimer’s disease
por: Franzmeier, Nicolai, et al.
Publicado: (2020)

Heterogeneous distribution of tau pathology in the behavioural variant of Alzheimer’s disease
por: Singleton, Ellen, et al.
Publicado: (2021)

(18)F‐AV‐1451 and CSF T‐tau and P‐tau as biomarkers in Alzheimer's disease
por: Mattsson, Niklas, et al.
Publicado: (2017)

Association Between Earliest Amyloid Uptake and Functional Connectivity in Cognitively Unimpaired Elderly
por: Hahn, Andreas, et al.
Publicado: (2019)

Do genetic factors contribute to sex-specific differences in resilience to amyloid pathology?
por: Groot, Colin, et al.
Publicado: (2022)

Comparing (18)F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease
por: Mattsson, Niklas, et al.
Publicado: (2018)

(18)F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
por: Tsai, Richard M., et al.
Publicado: (2019)

Longitudinal plasma p-tau217 is increased in early stages of Alzheimer’s disease
por: Mattsson-Carlgren, Niklas, et al.
Publicado: (2020)

Altered excitatory and inhibitory neuronal subpopulation parameters are distinctly associated with tau and amyloid in Alzheimer’s disease
por: Ranasinghe, Kamalini G, et al.
Publicado: (2022)

Atrophy of the Posterior Subiculum Is Associated with Memory Impairment, Tau- and Aβ Pathology in Non-demented Individuals
por: Lindberg, Olof, et al.
Publicado: (2017)

CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer’s disease
por: Horie, Kanta, et al.
Publicado: (2023)

Earlier Alzheimer’s disease onset is associated with tau pathology in brain hub regions and facilitated tau spreading
por: Frontzkowski, Lukas, et al.
Publicado: (2022)

Derivation and utility of an Aβ-PET pathology accumulation index to estimate Aβ load
por: Leuzy, Antoine, et al.
Publicado: (2020)

Microglial activation protects against accumulation of tau aggregates in nondemented individuals with underlying Alzheimer’s disease pathology
por: Pereira, Joana B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6mje2ocisqd7f1vp889afdul9j