Cargando…
mRNA modification orchestrates cancer stem cell fate decisions
Despite their small numbers, cancer stem cells play a central role in driving cancer cell growth, chemotherapeutic resistance, and distal metastasis. Previous studies mainly focused on how DNA or histone modification determines cell fate in cancer. However, it is still largely unknown how RNA modifi...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043046/ https://www.ncbi.nlm.nih.gov/pubmed/32101138 http://dx.doi.org/10.1186/s12943-020-01166-w |
_version_ | 1783501389601701888 |
---|---|
author | Liang, Weicheng Lin, Zexiao Du, Cong Qiu, Dongbo Zhang, Qi |
author_facet | Liang, Weicheng Lin, Zexiao Du, Cong Qiu, Dongbo Zhang, Qi |
author_sort | Liang, Weicheng |
collection | PubMed |
description | Despite their small numbers, cancer stem cells play a central role in driving cancer cell growth, chemotherapeutic resistance, and distal metastasis. Previous studies mainly focused on how DNA or histone modification determines cell fate in cancer. However, it is still largely unknown how RNA modifications orchestrate cancer cell fate decisions. More than 170 distinct RNA modifications have been identified in the RNA world, while only a few RNA base modifications have been found in mRNA. Growing evidence indicates that three mRNA modifications, inosine, 5-methylcytosine, and N(6)-methyladenosine, are essential for the regulation of spatiotemporal gene expression during cancer stem cell fate transition. Furthermore, transcriptome-wide mapping has found that the aberrant deposition of mRNA modification, which can disrupt the gene regulatory network and lead to uncontrollable cancer cell growth, is widespread across different cancers. In this review, we try to summarize the recent advances of these three mRNA modifications in maintaining the stemness of cancer stem cells and discuss the underlying molecular mechanisms, which will shed light on the development of novel therapeutic approaches for eradicating cancer stem cells. |
format | Online Article Text |
id | pubmed-7043046 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70430462020-03-03 mRNA modification orchestrates cancer stem cell fate decisions Liang, Weicheng Lin, Zexiao Du, Cong Qiu, Dongbo Zhang, Qi Mol Cancer Review Despite their small numbers, cancer stem cells play a central role in driving cancer cell growth, chemotherapeutic resistance, and distal metastasis. Previous studies mainly focused on how DNA or histone modification determines cell fate in cancer. However, it is still largely unknown how RNA modifications orchestrate cancer cell fate decisions. More than 170 distinct RNA modifications have been identified in the RNA world, while only a few RNA base modifications have been found in mRNA. Growing evidence indicates that three mRNA modifications, inosine, 5-methylcytosine, and N(6)-methyladenosine, are essential for the regulation of spatiotemporal gene expression during cancer stem cell fate transition. Furthermore, transcriptome-wide mapping has found that the aberrant deposition of mRNA modification, which can disrupt the gene regulatory network and lead to uncontrollable cancer cell growth, is widespread across different cancers. In this review, we try to summarize the recent advances of these three mRNA modifications in maintaining the stemness of cancer stem cells and discuss the underlying molecular mechanisms, which will shed light on the development of novel therapeutic approaches for eradicating cancer stem cells. BioMed Central 2020-02-26 /pmc/articles/PMC7043046/ /pubmed/32101138 http://dx.doi.org/10.1186/s12943-020-01166-w Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Liang, Weicheng Lin, Zexiao Du, Cong Qiu, Dongbo Zhang, Qi mRNA modification orchestrates cancer stem cell fate decisions |
title | mRNA modification orchestrates cancer stem cell fate decisions |
title_full | mRNA modification orchestrates cancer stem cell fate decisions |
title_fullStr | mRNA modification orchestrates cancer stem cell fate decisions |
title_full_unstemmed | mRNA modification orchestrates cancer stem cell fate decisions |
title_short | mRNA modification orchestrates cancer stem cell fate decisions |
title_sort | mrna modification orchestrates cancer stem cell fate decisions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043046/ https://www.ncbi.nlm.nih.gov/pubmed/32101138 http://dx.doi.org/10.1186/s12943-020-01166-w |
work_keys_str_mv | AT liangweicheng mrnamodificationorchestratescancerstemcellfatedecisions AT linzexiao mrnamodificationorchestratescancerstemcellfatedecisions AT ducong mrnamodificationorchestratescancerstemcellfatedecisions AT qiudongbo mrnamodificationorchestratescancerstemcellfatedecisions AT zhangqi mrnamodificationorchestratescancerstemcellfatedecisions |