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Recent advances in the understanding and management of primary hyperparathyroidism

Primary hyperparathyroidism is a hormonal disorder whose prevalence is approximately 1–2% in the United States of America. The disease has become more recognizable to clinicians in an earlier phase and, at present, patients can be diagnosed with “classic”, “normocalcemic”, “normohormonal”, or “mild,...

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Autores principales: Goldfarb, Melanie, Singer, Frederick R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043104/
https://www.ncbi.nlm.nih.gov/pubmed/32148764
http://dx.doi.org/10.12688/f1000research.21569.1
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author Goldfarb, Melanie
Singer, Frederick R.
author_facet Goldfarb, Melanie
Singer, Frederick R.
author_sort Goldfarb, Melanie
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description Primary hyperparathyroidism is a hormonal disorder whose prevalence is approximately 1–2% in the United States of America. The disease has become more recognizable to clinicians in an earlier phase and, at present, patients can be diagnosed with “classic”, “normocalcemic”, “normohormonal”, or “mild, asymptomatic” primary hyperparathyroidism. Surgery, with a focused parathyroidectomy when possible, or a four-gland exploration, is the only way to cure the disease. Cure is determined by use of intra-operative parathyroid hormone monitoring with long-term cure rates ranging from 90–95%. Newer adjuncts to surgery include CT or PET imaging and near-infrared immunofluorescence. This article highlights updates in parathyroid disease and advances in parathyroid surgery; it does not provide a comprehensive summary of the disease process or a review of surgical indications, which can be found in the AAES guidelines or NIH Symposium on primary hyperparathyroidism.
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spelling pubmed-70431042020-03-05 Recent advances in the understanding and management of primary hyperparathyroidism Goldfarb, Melanie Singer, Frederick R. F1000Res Review Primary hyperparathyroidism is a hormonal disorder whose prevalence is approximately 1–2% in the United States of America. The disease has become more recognizable to clinicians in an earlier phase and, at present, patients can be diagnosed with “classic”, “normocalcemic”, “normohormonal”, or “mild, asymptomatic” primary hyperparathyroidism. Surgery, with a focused parathyroidectomy when possible, or a four-gland exploration, is the only way to cure the disease. Cure is determined by use of intra-operative parathyroid hormone monitoring with long-term cure rates ranging from 90–95%. Newer adjuncts to surgery include CT or PET imaging and near-infrared immunofluorescence. This article highlights updates in parathyroid disease and advances in parathyroid surgery; it does not provide a comprehensive summary of the disease process or a review of surgical indications, which can be found in the AAES guidelines or NIH Symposium on primary hyperparathyroidism. F1000 Research Limited 2020-02-25 /pmc/articles/PMC7043104/ /pubmed/32148764 http://dx.doi.org/10.12688/f1000research.21569.1 Text en Copyright: © 2020 Goldfarb M and Singer FR http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Goldfarb, Melanie
Singer, Frederick R.
Recent advances in the understanding and management of primary hyperparathyroidism
title Recent advances in the understanding and management of primary hyperparathyroidism
title_full Recent advances in the understanding and management of primary hyperparathyroidism
title_fullStr Recent advances in the understanding and management of primary hyperparathyroidism
title_full_unstemmed Recent advances in the understanding and management of primary hyperparathyroidism
title_short Recent advances in the understanding and management of primary hyperparathyroidism
title_sort recent advances in the understanding and management of primary hyperparathyroidism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043104/
https://www.ncbi.nlm.nih.gov/pubmed/32148764
http://dx.doi.org/10.12688/f1000research.21569.1
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