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Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans

Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is foundational to the process of functional hypertrophy...

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Autores principales: Joanisse, Sophie, Lim, Changhyun, McKendry, James, Mcleod, Jonathan C., Stokes, Tanner, Phillips, Stuart M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043134/
https://www.ncbi.nlm.nih.gov/pubmed/32148775
http://dx.doi.org/10.12688/f1000research.21588.1
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author Joanisse, Sophie
Lim, Changhyun
McKendry, James
Mcleod, Jonathan C.
Stokes, Tanner
Phillips, Stuart M.
author_facet Joanisse, Sophie
Lim, Changhyun
McKendry, James
Mcleod, Jonathan C.
Stokes, Tanner
Phillips, Stuart M.
author_sort Joanisse, Sophie
collection PubMed
description Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is foundational to the process of functional hypertrophy. Much of our current understanding of skeletal muscle hypertrophy can be attributed to the development and utilization of stable isotopically labeled tracers. We know that resistance exercise and sufficient protein intake act synergistically and provide the most effective stimuli to enhance skeletal muscle mass; however, the molecular intricacies that underpin the tremendous response variability to resistance exercise-induced hypertrophy are complex. The purpose of this review is to discuss recent studies with the aim of shedding light on key regulatory mechanisms that dictate hypertrophic gains in skeletal muscle mass. We also aim to provide a brief up-to-date summary of the recent advances in our understanding of skeletal muscle hypertrophy in response to resistance training in humans.
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spelling pubmed-70431342020-03-05 Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans Joanisse, Sophie Lim, Changhyun McKendry, James Mcleod, Jonathan C. Stokes, Tanner Phillips, Stuart M. F1000Res Review Skeletal muscle plays a pivotal role in the maintenance of physical and metabolic health and, critically, mobility. Accordingly, strategies focused on increasing the quality and quantity of skeletal muscle are relevant, and resistance exercise is foundational to the process of functional hypertrophy. Much of our current understanding of skeletal muscle hypertrophy can be attributed to the development and utilization of stable isotopically labeled tracers. We know that resistance exercise and sufficient protein intake act synergistically and provide the most effective stimuli to enhance skeletal muscle mass; however, the molecular intricacies that underpin the tremendous response variability to resistance exercise-induced hypertrophy are complex. The purpose of this review is to discuss recent studies with the aim of shedding light on key regulatory mechanisms that dictate hypertrophic gains in skeletal muscle mass. We also aim to provide a brief up-to-date summary of the recent advances in our understanding of skeletal muscle hypertrophy in response to resistance training in humans. F1000 Research Limited 2020-02-24 /pmc/articles/PMC7043134/ /pubmed/32148775 http://dx.doi.org/10.12688/f1000research.21588.1 Text en Copyright: © 2020 Joanisse S et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Joanisse, Sophie
Lim, Changhyun
McKendry, James
Mcleod, Jonathan C.
Stokes, Tanner
Phillips, Stuart M.
Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
title Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
title_full Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
title_fullStr Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
title_full_unstemmed Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
title_short Recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
title_sort recent advances in understanding resistance exercise training-induced skeletal muscle hypertrophy in humans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043134/
https://www.ncbi.nlm.nih.gov/pubmed/32148775
http://dx.doi.org/10.12688/f1000research.21588.1
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