A Comprehensive Review of Ovarian Serous Carcinoma

Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carc...

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Autores principales: Hatano, Yuichiro, Hatano, Kayoko, Tamada, Maho, Morishige, Ken-ichirou, Tomita, Hiroyuki, Yanai, Hiroyuki, Hara, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043727/
https://www.ncbi.nlm.nih.gov/pubmed/31368906
http://dx.doi.org/10.1097/PAP.0000000000000243
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author Hatano, Yuichiro
Hatano, Kayoko
Tamada, Maho
Morishige, Ken-ichirou
Tomita, Hiroyuki
Yanai, Hiroyuki
Hara, Akira
author_facet Hatano, Yuichiro
Hatano, Kayoko
Tamada, Maho
Morishige, Ken-ichirou
Tomita, Hiroyuki
Yanai, Hiroyuki
Hara, Akira
author_sort Hatano, Yuichiro
collection PubMed
description Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma.
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spelling pubmed-70437272020-03-10 A Comprehensive Review of Ovarian Serous Carcinoma Hatano, Yuichiro Hatano, Kayoko Tamada, Maho Morishige, Ken-ichirou Tomita, Hiroyuki Yanai, Hiroyuki Hara, Akira Adv Anat Pathol Review Article Although ovarian serous carcinoma is a well-studied human gynecologic malignancy, this high-grade tumor remains fatal. The main purpose of this review is to summarize the accumulated evidence on serous malignant tumors and to clarify the unresolved issues. We discuss the 8 dichotomies of serous carcinoma: high grade versus low grade, ovarian versus extraovarian primary, extrauterine versus uterine primary, sporadic versus hereditary, orthodox versus alternative histology, p53 overexpression versus complete absence of immunophenotype, TP53-mutated versus intact precursor, and therapy responsive versus refractory. In addition, we summarize the molecular classification of high-grade serous carcinoma. This review would lead readers to rapid and parallel developments in understanding high-grade serous carcinoma. Lippincott Williams & Wilkins 2019-09 2019-07-26 /pmc/articles/PMC7043727/ /pubmed/31368906 http://dx.doi.org/10.1097/PAP.0000000000000243 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review Article
Hatano, Yuichiro
Hatano, Kayoko
Tamada, Maho
Morishige, Ken-ichirou
Tomita, Hiroyuki
Yanai, Hiroyuki
Hara, Akira
A Comprehensive Review of Ovarian Serous Carcinoma
title A Comprehensive Review of Ovarian Serous Carcinoma
title_full A Comprehensive Review of Ovarian Serous Carcinoma
title_fullStr A Comprehensive Review of Ovarian Serous Carcinoma
title_full_unstemmed A Comprehensive Review of Ovarian Serous Carcinoma
title_short A Comprehensive Review of Ovarian Serous Carcinoma
title_sort comprehensive review of ovarian serous carcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043727/
https://www.ncbi.nlm.nih.gov/pubmed/31368906
http://dx.doi.org/10.1097/PAP.0000000000000243
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