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Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma

PURPOSE: Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas. Data concerning their ethnic distributions are diverse which explains why their biological characteristi...

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Autores principales: Zouine, Soukaina, Marnissi, Farida, Otmani, Nada, Bennani Othmani, Mohamed, Zaid, Nabil, Kojok, Kevin, Zaid, Younes, Tahiri Jouti, Nadia, Habti, Norddine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Breast Cancer Society 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043947/
https://www.ncbi.nlm.nih.gov/pubmed/32140271
http://dx.doi.org/10.4048/jbc.2020.23.e13
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author Zouine, Soukaina
Marnissi, Farida
Otmani, Nada
Bennani Othmani, Mohamed
Zaid, Nabil
Kojok, Kevin
Zaid, Younes
Tahiri Jouti, Nadia
Habti, Norddine
author_facet Zouine, Soukaina
Marnissi, Farida
Otmani, Nada
Bennani Othmani, Mohamed
Zaid, Nabil
Kojok, Kevin
Zaid, Younes
Tahiri Jouti, Nadia
Habti, Norddine
author_sort Zouine, Soukaina
collection PubMed
description PURPOSE: Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas. Data concerning their ethnic distributions are diverse which explains why their biological characteristics have to be studied in different populations. Our aim was to analyze the expression of the histo-blood group (specifically the ABH) antigens in breast carcinoma. METHODS: The expression of the histo-blood group (specifically the ABH) antigens was studied in 109 patients with breast carcinoma using immunohistochemistry. Statistical analysis was performed using χ(2) and Fisher analyses. RESULTS: The loss of expression of histo-blood group (ABH) antigens in breast carcinoma was observed in 81.13% of patients with blood group O, 37.93% with blood group A, and 96.30% with blood group B. One key finding of this study was that the loss of expression of the ABH antigen was also observed in normal tissues adjacent to the tumor. The loss of expression was associated with higher tumor grade (p < 0.05). Expression of H antigen was observed in 50% of cases with loss of expression of B antigen and was associated with human epidermal growth factor receptor 2 (HER2) overexpression (p < 0.05). The loss of H antigen in patients with blood group O was associated with estrogen receptor expression (p < 0.001). Incompatible A antigen in tumor was expressed in 20.75% of patients with blood group O. CONCLUSION: Loss of the ABH antigens correlated with the Scarff-Bloom-Richardson histologic grading. H antigen was associated with HER2 overexpression in breast cancer. However, further studies are needed to determine the role of incompatible A antigen in mammary carcinogenesis.
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spelling pubmed-70439472020-03-05 Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma Zouine, Soukaina Marnissi, Farida Otmani, Nada Bennani Othmani, Mohamed Zaid, Nabil Kojok, Kevin Zaid, Younes Tahiri Jouti, Nadia Habti, Norddine J Breast Cancer Original Article PURPOSE: Aberrant glycosylation of the histo-blood group antigens (including the angina bullosa haemorrhagica [ABH]) is often observed during malignant transformation in most types of carcinomas. Data concerning their ethnic distributions are diverse which explains why their biological characteristics have to be studied in different populations. Our aim was to analyze the expression of the histo-blood group (specifically the ABH) antigens in breast carcinoma. METHODS: The expression of the histo-blood group (specifically the ABH) antigens was studied in 109 patients with breast carcinoma using immunohistochemistry. Statistical analysis was performed using χ(2) and Fisher analyses. RESULTS: The loss of expression of histo-blood group (ABH) antigens in breast carcinoma was observed in 81.13% of patients with blood group O, 37.93% with blood group A, and 96.30% with blood group B. One key finding of this study was that the loss of expression of the ABH antigen was also observed in normal tissues adjacent to the tumor. The loss of expression was associated with higher tumor grade (p < 0.05). Expression of H antigen was observed in 50% of cases with loss of expression of B antigen and was associated with human epidermal growth factor receptor 2 (HER2) overexpression (p < 0.05). The loss of H antigen in patients with blood group O was associated with estrogen receptor expression (p < 0.001). Incompatible A antigen in tumor was expressed in 20.75% of patients with blood group O. CONCLUSION: Loss of the ABH antigens correlated with the Scarff-Bloom-Richardson histologic grading. H antigen was associated with HER2 overexpression in breast cancer. However, further studies are needed to determine the role of incompatible A antigen in mammary carcinogenesis. Korean Breast Cancer Society 2020-01-29 /pmc/articles/PMC7043947/ /pubmed/32140271 http://dx.doi.org/10.4048/jbc.2020.23.e13 Text en © 2020 Korean Breast Cancer Society https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Zouine, Soukaina
Marnissi, Farida
Otmani, Nada
Bennani Othmani, Mohamed
Zaid, Nabil
Kojok, Kevin
Zaid, Younes
Tahiri Jouti, Nadia
Habti, Norddine
Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma
title Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma
title_full Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma
title_fullStr Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma
title_full_unstemmed Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma
title_short Expression of Histo-blood Group Antigens in Tumor and Adjacent Normal Breast Tissues as Prognostic Markers of Breast Carcinoma
title_sort expression of histo-blood group antigens in tumor and adjacent normal breast tissues as prognostic markers of breast carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043947/
https://www.ncbi.nlm.nih.gov/pubmed/32140271
http://dx.doi.org/10.4048/jbc.2020.23.e13
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