Cargando…

Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated with the suppressing renal connective tissue growth factor e...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Sundong, Yu, Lechu, Ni, Yongqing, He, Lulu, Weng, Xiaolu, Lu, Xuemian, Zhang, Chi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Diabetes Association 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043973/ https://www.ncbi.nlm.nih.gov/pubmed/31701691 http://dx.doi.org/10.4093/dmj.2018.0235

Ejemplares similares

Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
por: Yang, Hong, et al.
Publicado: (2018)

Therapeutic Effects of Fibroblast Growth Factor-21 on Diabetic Nephropathy and the Possible Mechanism in Type 1 Diabetes Mellitus Mice
por: Weng, Wenya, et al.
Publicado: (2020)

Attenuation of Hyperlipidemia- and Diabetes-Induced Early-Stage Apoptosis and Late-Stage Renal Dysfunction via Administration of Fibroblast Growth Factor-21 Is Associated with Suppression of Renal Inflammation
por: Zhang, Chi, et al.
Publicado: (2013)

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation
por: Loboda, Agnieszka, et al.
Publicado: (2016)

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts
por: Wan, Ruyan, et al.
Publicado: (2023)

Acupuncture attenuates renal interstitial fibrosis via the TGF-β/Smad pathway
por: Zuo, Zheng, et al.
Publicado: (2019)

Aspirin attenuates liver fibrosis by suppressing TGF-β1/Smad signaling
por: Sun, Yimin, et al.
Publicado: (2022)

Liquiritigenin attenuates isoprenaline-induced myocardial fibrosis in mice through the TGF-β1/Smad2 and AKT/ERK signaling pathways
por: Li, Li, et al.
Publicado: (2021)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation
por: Wang, Ruichen, et al.
Publicado: (2021)

Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy via the TGF-β–Smad3 Pathway
por: Wang, Yinhui, et al.
Publicado: (2021)

Tyrosine kinase receptor B attenuates liver fibrosis by inhibiting TGF-β/SMAD signaling
por: Song, Yu, et al.
Publicado: (2023)

Interleukin-19 Aggravates Pulmonary Fibrosis via Activating Fibroblast through TGF-β/Smad Pathway
por: Wang, Yu, et al.
Publicado: (2022)

Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
por: Cheng, Peng, et al.
Publicado: (2016)

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways
por: Gao, Lei, et al.
Publicado: (2020)

Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways
por: Shi, Wei, et al.
Publicado: (2021)

Catalpol Attenuates Pulmonary Fibrosis by Inhibiting Ang II/AT(1) and TGF-β/Smad-Mediated Epithelial Mesenchymal Transition
por: Yu, Qun, et al.
Publicado: (2022)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

Blueberry Juice Attenuates Pulmonary Fibrosis via Blocking the TGF-β1/Smad Signaling Pathway
por: Li, Yali, et al.
Publicado: (2022)

2-Arachidonoylglycerol Attenuates Myocardial Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway
por: Chen, Zhengjie, et al.
Publicado: (2022)

Hepatocyte-Specific Ablation of PP2A Catalytic Subunit α Attenuates Liver Fibrosis Progression via TGF-β1/Smad Signaling
por: Lu, Na, et al.
Publicado: (2015)

Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
por: Lan, Hui Yao
Publicado: (2011)

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis
por: Walton, Kelly L., et al.
Publicado: (2017)

Casticin attenuates liver fibrosis and hepatic stellate cell activation by blocking TGF-β/Smad signaling pathway
por: Zhou, Ling, et al.
Publicado: (2017)

Kangfuxin Oral Liquid Attenuates Bleomycin-Induced Pulmonary Fibrosis via the TGF-β1/Smad Pathway
por: Yao, Huan, et al.
Publicado: (2019)

Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/Smad2 signalling pathway
por: Li, Zhaoyi, et al.
Publicado: (2022)

SKIL/SnoN attenuates TGF-β1/SMAD signaling-dependent collagen synthesis in hepatic fibrosis
por: Chi, Cheng, et al.
Publicado: (2023)

Atorvastatin attenuates TGF-β1-induced fibrogenesis by inhibiting Smad3 and MAPK signaling in human ventricular fibroblasts
por: Du, Yanfei, et al.
Publicado: (2020)

Amelioration of bleomycin-induced pulmonary fibrosis via TGF-β-induced Smad and non-Smad signaling pathways in galectin-9-deficient mice and fibroblast cells
por: Hsu, Yu-An, et al.
Publicado: (2020)

Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways
por: Yao, Lixia, et al.
Publicado: (2021)

TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways
por: Zhao, Zhenzhen, et al.
Publicado: (2022)

Suppression of TGF-β(1)/Smad Signaling Pathway by Sesamin Contributes to the Attenuation of Myocardial Fibrosis in Spontaneously Hypertensive Rats
por: Zhao, Mengqiu, et al.
Publicado: (2015)

ENMD-1068 inhibits liver fibrosis through attenuation of TGF-β1/Smad2/3 signaling in mice
por: Sun, Quan, et al.
Publicado: (2017)

DPP-4 Inhibitors Attenuate Fibrosis After Glaucoma Filtering Surgery by Suppressing the TGF-β/Smad Signaling Pathway
por: Yoshida, Masaaki, et al.
Publicado: (2023)

ZD6474 attenuates TGF-β1-induced fibrosis in human Tenon fibroblasts and inhibits neovascularization via AKT-mTOR signaling pathway
por: Liu, Wenting, et al.
Publicado: (2022)

Ferulic Acid Attenuates TGF-β1-Induced Renal Cellular Fibrosis in NRK-52E Cells by Inhibiting Smad/ILK/Snail Pathway
por: Wei, Ming-gang, et al.
Publicado: (2015)

Role of TGF-Beta and Smad7 in Gut Inflammation, Fibrosis and Cancer
por: Stolfi, Carmine, et al.
Publicado: (2020)

Inhibition of microRNA-21 decreases the invasiveness of fibroblast-like synoviocytes in rheumatoid arthritis via TGF(β)/Smads signaling pathway
por: Xiong, Gaoxin, et al.
Publicado: (2016)

Naringenin prevents experimental liver fibrosis by blocking TGFβ-Smad3 and JNK-Smad3 pathways
por: Hernández-Aquino, Erika, et al.
Publicado: (2017)

Macrophage-Stimulated Cardiac Fibroblast Production of IL-6 Is Essential for TGF β/Smad Activation and Cardiac Fibrosis Induced by Angiotensin II
por: Ma, Feifei, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tjq1ijj9f6u9fdlpod0m9omkp1