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Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women

BACKGROUND: Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown. Here, we investigated whether a combined exercise can alter the circulating Apo...

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Autores principales: Jeon, Yun Kyung, Kim, Sang Soo, Kim, Jong Ho, Kim, Hyun Jeong, Kim, Hyun Jun, Park, Jang Jun, Cho, Yuen Suk, Joung, So Hee, Kim, Ji Ryang, Kim, Bo Hyun, Song, Sang Heon, Kim, In Joo, Kim, Yong Ki, Kim, Young-Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043986/
https://www.ncbi.nlm.nih.gov/pubmed/32097999
http://dx.doi.org/10.4093/dmj.2018.0160
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author Jeon, Yun Kyung
Kim, Sang Soo
Kim, Jong Ho
Kim, Hyun Jeong
Kim, Hyun Jun
Park, Jang Jun
Cho, Yuen Suk
Joung, So Hee
Kim, Ji Ryang
Kim, Bo Hyun
Song, Sang Heon
Kim, In Joo
Kim, Yong Ki
Kim, Young-Bum
author_facet Jeon, Yun Kyung
Kim, Sang Soo
Kim, Jong Ho
Kim, Hyun Jeong
Kim, Hyun Jun
Park, Jang Jun
Cho, Yuen Suk
Joung, So Hee
Kim, Ji Ryang
Kim, Bo Hyun
Song, Sang Heon
Kim, In Joo
Kim, Yong Ki
Kim, Young-Bum
author_sort Jeon, Yun Kyung
collection PubMed
description BACKGROUND: Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown. Here, we investigated whether a combined exercise can alter the circulating ApoJ level, and whether these changes are associated with metabolic indices in patients with type 2 diabetes mellitus. METHODS: Postmenopausal women with type 2 diabetes mellitus were randomly assigned into either an exercise (EXE, n=30) or control (CON, n=15) group. Participants in the EXE group were enrolled in a 12-week program consisting of a combination of aerobic and resistance exercises. At baseline, 4, 8, and 12 weeks, body composition and metabolic parameters including homeostatic model assessment of insulin resistance (HOMA-IR) and serum ApoJ levels were assessed. RESULTS: In the EXE group, ApoJ levels decreased 26.3% and 19.4%, relative to baseline, at 8 and 12 weeks, respectively. Between-group differences were significant at 8 and 12 weeks (P<0.05 and P<0.001, respectively). In the EXE group, 12 weeks of exercise resulted in significant decreases in body weight, percent body fat, and HOMA-IR indices. Concurrently, weight-adjusted appendicular skeletal muscle mass (ASM/wt) was increased in the EXE group compared with the CON group. Importantly, changes in the ApoJ level were significantly correlated with changes in ASM/wt. CONCLUSION: Exercise training resulted in a significant decrease in the circulating ApoJ level, with changes in ApoJ associated with an improvement in some insulin resistance indices. These data suggest that circulating ApoJ may be a useful metabolic marker for assessing the effects of exercise on insulin resistance.
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spelling pubmed-70439862020-03-05 Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women Jeon, Yun Kyung Kim, Sang Soo Kim, Jong Ho Kim, Hyun Jeong Kim, Hyun Jun Park, Jang Jun Cho, Yuen Suk Joung, So Hee Kim, Ji Ryang Kim, Bo Hyun Song, Sang Heon Kim, In Joo Kim, Yong Ki Kim, Young-Bum Diabetes Metab J Original Article BACKGROUND: Circulating apolipoprotein J (ApoJ) is closely associated with insulin resistance; however, the effect of exercise on circulating ApoJ levels and the association of ApoJ with metabolic indices remain unknown. Here, we investigated whether a combined exercise can alter the circulating ApoJ level, and whether these changes are associated with metabolic indices in patients with type 2 diabetes mellitus. METHODS: Postmenopausal women with type 2 diabetes mellitus were randomly assigned into either an exercise (EXE, n=30) or control (CON, n=15) group. Participants in the EXE group were enrolled in a 12-week program consisting of a combination of aerobic and resistance exercises. At baseline, 4, 8, and 12 weeks, body composition and metabolic parameters including homeostatic model assessment of insulin resistance (HOMA-IR) and serum ApoJ levels were assessed. RESULTS: In the EXE group, ApoJ levels decreased 26.3% and 19.4%, relative to baseline, at 8 and 12 weeks, respectively. Between-group differences were significant at 8 and 12 weeks (P<0.05 and P<0.001, respectively). In the EXE group, 12 weeks of exercise resulted in significant decreases in body weight, percent body fat, and HOMA-IR indices. Concurrently, weight-adjusted appendicular skeletal muscle mass (ASM/wt) was increased in the EXE group compared with the CON group. Importantly, changes in the ApoJ level were significantly correlated with changes in ASM/wt. CONCLUSION: Exercise training resulted in a significant decrease in the circulating ApoJ level, with changes in ApoJ associated with an improvement in some insulin resistance indices. These data suggest that circulating ApoJ may be a useful metabolic marker for assessing the effects of exercise on insulin resistance. Korean Diabetes Association 2020-02 2020-02-21 /pmc/articles/PMC7043986/ /pubmed/32097999 http://dx.doi.org/10.4093/dmj.2018.0160 Text en Copyright © 2020 Korean Diabetes Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jeon, Yun Kyung
Kim, Sang Soo
Kim, Jong Ho
Kim, Hyun Jeong
Kim, Hyun Jun
Park, Jang Jun
Cho, Yuen Suk
Joung, So Hee
Kim, Ji Ryang
Kim, Bo Hyun
Song, Sang Heon
Kim, In Joo
Kim, Yong Ki
Kim, Young-Bum
Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
title Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
title_full Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
title_fullStr Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
title_full_unstemmed Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
title_short Combined Aerobic and Resistance Exercise Training Reduces Circulating Apolipoprotein J Levels and Improves Insulin Resistance in Postmenopausal Diabetic Women
title_sort combined aerobic and resistance exercise training reduces circulating apolipoprotein j levels and improves insulin resistance in postmenopausal diabetic women
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7043986/
https://www.ncbi.nlm.nih.gov/pubmed/32097999
http://dx.doi.org/10.4093/dmj.2018.0160
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