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Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves

BACKGROUND: Household air pollution from solid fuels is a leading risk factor for morbidity and mortality worldwide. Pregnant women’s exposure to polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), two components of solid fuel smoke, is associated with adverse birth outcom...

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Autores principales: Weinstein, John R., Diaz-Artiga, Anaité, Benowitz, Neal, Thompson, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044065/
https://www.ncbi.nlm.nih.gov/pubmed/31477781
http://dx.doi.org/10.1038/s41370-019-0163-0
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author Weinstein, John R.
Diaz-Artiga, Anaité
Benowitz, Neal
Thompson, Lisa M.
author_facet Weinstein, John R.
Diaz-Artiga, Anaité
Benowitz, Neal
Thompson, Lisa M.
author_sort Weinstein, John R.
collection PubMed
description BACKGROUND: Household air pollution from solid fuels is a leading risk factor for morbidity and mortality worldwide. Pregnant women’s exposure to polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), two components of solid fuel smoke, is associated with adverse birth outcomes. Even with improved solid fuel stoves, exposure to PAHs and VOCs remains high. Therefore, cleaner cooking fuels need to be prioritized. OBJECTIVE: We aimed to quantify exposure reduction to PAHs and VOCs among pregnant women in rural Guatemala with a liquefied petroleum gas (LPG) stove intervention. MATERIALS AND METHODS: Urine from pregnant women (N=50) was collected twice: at < 20 weeks gestation, when women cooked exclusively with wood, and 6–8 weeks after receiving an LPG stove. Metabolites of 4 PAHs and 8 VOCs were analyzed. Concurrent with urine collection, personal 48-hour PM(2.5) exposure was measured. RESULTS: Women cooking exclusively with wood were exposed to high levels of particulate matter (PM(2.5)), which was reduced by 57% with the LPG stove. Urinary concentrations of total PAH metabolites (−37%), PMA (benzene metabolite; −49%), and CNEMA (acrylonitrile metabolite; −51%) were reduced. However, recent use of a wood-fired sauna bath led to large increases in excretion of urinary toxicant metabolites (+66–135%). CONCLUSIONS: This is the first study to report PAH and VOC reductions from an LPG stove intervention introduced during pregnancy. However, other sources of air pollution minimized the gains seen from using an LPG stove. Thus, all sources of air pollution must be addressed in concert to reduce exposures to levels that protect health.
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spelling pubmed-70440652020-03-02 Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves Weinstein, John R. Diaz-Artiga, Anaité Benowitz, Neal Thompson, Lisa M. J Expo Sci Environ Epidemiol Article BACKGROUND: Household air pollution from solid fuels is a leading risk factor for morbidity and mortality worldwide. Pregnant women’s exposure to polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), two components of solid fuel smoke, is associated with adverse birth outcomes. Even with improved solid fuel stoves, exposure to PAHs and VOCs remains high. Therefore, cleaner cooking fuels need to be prioritized. OBJECTIVE: We aimed to quantify exposure reduction to PAHs and VOCs among pregnant women in rural Guatemala with a liquefied petroleum gas (LPG) stove intervention. MATERIALS AND METHODS: Urine from pregnant women (N=50) was collected twice: at < 20 weeks gestation, when women cooked exclusively with wood, and 6–8 weeks after receiving an LPG stove. Metabolites of 4 PAHs and 8 VOCs were analyzed. Concurrent with urine collection, personal 48-hour PM(2.5) exposure was measured. RESULTS: Women cooking exclusively with wood were exposed to high levels of particulate matter (PM(2.5)), which was reduced by 57% with the LPG stove. Urinary concentrations of total PAH metabolites (−37%), PMA (benzene metabolite; −49%), and CNEMA (acrylonitrile metabolite; −51%) were reduced. However, recent use of a wood-fired sauna bath led to large increases in excretion of urinary toxicant metabolites (+66–135%). CONCLUSIONS: This is the first study to report PAH and VOC reductions from an LPG stove intervention introduced during pregnancy. However, other sources of air pollution minimized the gains seen from using an LPG stove. Thus, all sources of air pollution must be addressed in concert to reduce exposures to levels that protect health. 2019-09-02 2020-03 /pmc/articles/PMC7044065/ /pubmed/31477781 http://dx.doi.org/10.1038/s41370-019-0163-0 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Weinstein, John R.
Diaz-Artiga, Anaité
Benowitz, Neal
Thompson, Lisa M.
Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves
title Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves
title_full Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves
title_fullStr Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves
title_full_unstemmed Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves
title_short Reductions in urinary metabolites of exposure to household air pollution in pregnant, rural Guatemalan women provided liquefied petroleum gas stoves
title_sort reductions in urinary metabolites of exposure to household air pollution in pregnant, rural guatemalan women provided liquefied petroleum gas stoves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044065/
https://www.ncbi.nlm.nih.gov/pubmed/31477781
http://dx.doi.org/10.1038/s41370-019-0163-0
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