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Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI
BACKGROUND: Ruminative responding involves repetitive and passive thinking about one’s negative affect. This tendency interferes with initiation of goal-directed rewarding strategies, which could alleviate depressive states. Such reward-directed response selection has been shown to be mediated by ve...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044182/ https://www.ncbi.nlm.nih.gov/pubmed/32153443 http://dx.doi.org/10.3389/fpsyt.2020.00067 |
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author | Erdman, Alon Abend, Rany Jalon, Itamar Artzi, Moran Gazit, Tomer Avirame, Keren Ais, Ezequiel Diego Levokovitz, Hilik Gilboa-Schechtman, Eva Hendler, Talma Harel, Eiran Vadim |
author_facet | Erdman, Alon Abend, Rany Jalon, Itamar Artzi, Moran Gazit, Tomer Avirame, Keren Ais, Ezequiel Diego Levokovitz, Hilik Gilboa-Schechtman, Eva Hendler, Talma Harel, Eiran Vadim |
author_sort | Erdman, Alon |
collection | PubMed |
description | BACKGROUND: Ruminative responding involves repetitive and passive thinking about one’s negative affect. This tendency interferes with initiation of goal-directed rewarding strategies, which could alleviate depressive states. Such reward-directed response selection has been shown to be mediated by ventral striatum/nucleus accumbens (VS/NAcc) function. However, to date, no study has examined whether trait rumination relates to VS/NAcc functionality. Here, we tested whether rumination moderates VS/NAcc function both in response to reward and during a ruminative state. METHODS: Trait rumination was considered dimensionally using Rumination Response Scale (RRS) scores. Our sample (N = 80) consisted of individuals from a community sample and from patients diagnosed with major depressive disorder, providing a broad range of RRS scores. Participants underwent fMRI to assess two modes of VS/NAcc functionality: 1) in response to reward, and 2) during resting-state, as a proxy for ruminative state. We then tested for associations between RRS scores and VS/NAcc functional profiles, statistically controlling for overall depressive symptom severity. RESULTS: RRS scores correlated positively with VS/NAcc response to reward. Furthermore, we noted that higher RRS scores were associated with increased ruminative-dependent resting-state functional connectivity of the VS/NAcc with the left orbitofrontal cortex. CONCLUSIONS: These findings suggest that ruminative tendencies manifest in VS/NAcc reward- and rumination-related functions, providing support for a theoretical-clinical perspective of rumination as a habitual impairment in selection of rewarding, adaptive coping strategies. |
format | Online Article Text |
id | pubmed-7044182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70441822020-03-09 Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI Erdman, Alon Abend, Rany Jalon, Itamar Artzi, Moran Gazit, Tomer Avirame, Keren Ais, Ezequiel Diego Levokovitz, Hilik Gilboa-Schechtman, Eva Hendler, Talma Harel, Eiran Vadim Front Psychiatry Psychiatry BACKGROUND: Ruminative responding involves repetitive and passive thinking about one’s negative affect. This tendency interferes with initiation of goal-directed rewarding strategies, which could alleviate depressive states. Such reward-directed response selection has been shown to be mediated by ventral striatum/nucleus accumbens (VS/NAcc) function. However, to date, no study has examined whether trait rumination relates to VS/NAcc functionality. Here, we tested whether rumination moderates VS/NAcc function both in response to reward and during a ruminative state. METHODS: Trait rumination was considered dimensionally using Rumination Response Scale (RRS) scores. Our sample (N = 80) consisted of individuals from a community sample and from patients diagnosed with major depressive disorder, providing a broad range of RRS scores. Participants underwent fMRI to assess two modes of VS/NAcc functionality: 1) in response to reward, and 2) during resting-state, as a proxy for ruminative state. We then tested for associations between RRS scores and VS/NAcc functional profiles, statistically controlling for overall depressive symptom severity. RESULTS: RRS scores correlated positively with VS/NAcc response to reward. Furthermore, we noted that higher RRS scores were associated with increased ruminative-dependent resting-state functional connectivity of the VS/NAcc with the left orbitofrontal cortex. CONCLUSIONS: These findings suggest that ruminative tendencies manifest in VS/NAcc reward- and rumination-related functions, providing support for a theoretical-clinical perspective of rumination as a habitual impairment in selection of rewarding, adaptive coping strategies. Frontiers Media S.A. 2020-02-20 /pmc/articles/PMC7044182/ /pubmed/32153443 http://dx.doi.org/10.3389/fpsyt.2020.00067 Text en Copyright © 2020 Erdman, Abend, Jalon, Artzi, Gazit, Avirame, Ais, Levokovitz, Gilboa-Schechtman, Hendler and Harel http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Erdman, Alon Abend, Rany Jalon, Itamar Artzi, Moran Gazit, Tomer Avirame, Keren Ais, Ezequiel Diego Levokovitz, Hilik Gilboa-Schechtman, Eva Hendler, Talma Harel, Eiran Vadim Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI |
title | Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI |
title_full | Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI |
title_fullStr | Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI |
title_full_unstemmed | Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI |
title_short | Ruminative Tendency Relates to Ventral Striatum Functionality: Evidence From Task and Resting-State fMRI |
title_sort | ruminative tendency relates to ventral striatum functionality: evidence from task and resting-state fmri |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044182/ https://www.ncbi.nlm.nih.gov/pubmed/32153443 http://dx.doi.org/10.3389/fpsyt.2020.00067 |
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