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Caspase-11 promotes allergic airway inflammation

Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E(2) (PGE(2)) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE(2) suppreses caspase-11 expression in murine and human macrophages and in the...

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Detalles Bibliográficos
Autores principales:	Zasłona, Zbigniew, Flis, Ewelina, Wilk, Mieszko M., Carroll, Richard G., Palsson-McDermott, Eva M., Hughes, Mark M., Diskin, Ciana, Banahan, Kathy, Ryan, Dylan G., Hooftman, Alexander, Misiak, Alicja, Kearney, Jay, Lochnit, Gunter, Bertrams, Wilhelm, Greulich, Timm, Schmeck, Bernd, McElvaney, Oliver J., Mills, Kingston H. G., Lavelle, Ed C., Wygrecka, Małgorzata, Creagh, Emma M., O’Neill, Luke A. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044193/ https://www.ncbi.nlm.nih.gov/pubmed/32103022 http://dx.doi.org/10.1038/s41467-020-14945-2

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