B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show that the B38-CAP, a carboxypeptidase derived from Paenibacillus sp. B38, is an ACE2-like enzyme to decrease angiot...

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Detalles Bibliográficos
Autores principales: Minato, Takafumi, Nirasawa, Satoru, Sato, Teruki, Yamaguchi, Tomokazu, Hoshizaki, Midori, Inagaki, Tadakatsu, Nakahara, Kazuhiko, Yoshihashi, Tadashi, Ozawa, Ryo, Yokota, Saki, Natsui, Miyuki, Koyota, Souichi, Yoshiya, Taku, Yoshizawa-Kumagaye, Kumiko, Motoyama, Satoru, Gotoh, Takeshi, Nakaoka, Yoshikazu, Penninger, Josef M., Watanabe, Hiroyuki, Imai, Yumiko, Takahashi, Saori, Kuba, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044196/
https://www.ncbi.nlm.nih.gov/pubmed/32103002
http://dx.doi.org/10.1038/s41467-020-14867-z

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