The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer

Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area les...

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Detalles Bibliográficos
Autores principales: Patel, Akshay J., Richter, Alex, Drayson, Mark T., Middleton, Gary W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044257/
https://www.ncbi.nlm.nih.gov/pubmed/31901949
http://dx.doi.org/10.1007/s00262-019-02461-2
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author Patel, Akshay J.
Richter, Alex
Drayson, Mark T.
Middleton, Gary W.
author_facet Patel, Akshay J.
Richter, Alex
Drayson, Mark T.
Middleton, Gary W.
author_sort Patel, Akshay J.
collection PubMed
description Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer.
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spelling pubmed-70442572020-03-10 The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer Patel, Akshay J. Richter, Alex Drayson, Mark T. Middleton, Gary W. Cancer Immunol Immunother Review Tumour-infiltrating immune cells have been widely implicated to play a significant role in carcinogenesis, through both pro- or anti-tumour effects. The multi-faceted effects of lung cancer associated T lymphocytes have been extensively studied, and yet, the role of B lymphocytes remains an area less studied. In this review, we will describe the current understanding of the role of tumour-infiltrating B lymphocytes in NSCLC, discuss their prognostic significance, their functionality within the tumour microenvironment and ultimately how we might harness B-cell biology to develop B-cell therapeutic strategies in cancer. Springer Berlin Heidelberg 2020-01-04 2020 /pmc/articles/PMC7044257/ /pubmed/31901949 http://dx.doi.org/10.1007/s00262-019-02461-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Patel, Akshay J.
Richter, Alex
Drayson, Mark T.
Middleton, Gary W.
The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
title The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
title_full The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
title_fullStr The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
title_full_unstemmed The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
title_short The role of B lymphocytes in the immuno-biology of non-small-cell lung cancer
title_sort role of b lymphocytes in the immuno-biology of non-small-cell lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044257/
https://www.ncbi.nlm.nih.gov/pubmed/31901949
http://dx.doi.org/10.1007/s00262-019-02461-2
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