Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations

This case suggests a mechanistic rationale for the clinical efficacy of intravenous immunoglobulins (IVIG) in treating CD40 ligand (CD40L) deficiency associated neutropenia as it is the first reported instance of free and cell‐bound antineutrophil antibodies in a case of CD40L deficiency, accompanie...

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Autores principales: Assing, Kristian, Nielsen, Kaspar René, Tenstad, Helene Broch, Jakobsen, Marianne Antonius, Nielsen, Christian, Grosen, Dorthe, Hartling, Ulla Birgitte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044354/
https://www.ncbi.nlm.nih.gov/pubmed/32128179
http://dx.doi.org/10.1002/ccr3.2621
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author Assing, Kristian
Nielsen, Kaspar René
Tenstad, Helene Broch
Jakobsen, Marianne Antonius
Nielsen, Christian
Grosen, Dorthe
Hartling, Ulla Birgitte
author_facet Assing, Kristian
Nielsen, Kaspar René
Tenstad, Helene Broch
Jakobsen, Marianne Antonius
Nielsen, Christian
Grosen, Dorthe
Hartling, Ulla Birgitte
author_sort Assing, Kristian
collection PubMed
description This case suggests a mechanistic rationale for the clinical efficacy of intravenous immunoglobulins (IVIG) in treating CD40 ligand (CD40L) deficiency associated neutropenia as it is the first reported instance of free and cell‐bound antineutrophil antibodies in a case of CD40L deficiency, accompanied by a prolonged and clinically severe neutropenia.
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spelling pubmed-70443542020-03-03 Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations Assing, Kristian Nielsen, Kaspar René Tenstad, Helene Broch Jakobsen, Marianne Antonius Nielsen, Christian Grosen, Dorthe Hartling, Ulla Birgitte Clin Case Rep Case Reports This case suggests a mechanistic rationale for the clinical efficacy of intravenous immunoglobulins (IVIG) in treating CD40 ligand (CD40L) deficiency associated neutropenia as it is the first reported instance of free and cell‐bound antineutrophil antibodies in a case of CD40L deficiency, accompanied by a prolonged and clinically severe neutropenia. John Wiley and Sons Inc. 2019-12-25 /pmc/articles/PMC7044354/ /pubmed/32128179 http://dx.doi.org/10.1002/ccr3.2621 Text en © 2019 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Assing, Kristian
Nielsen, Kaspar René
Tenstad, Helene Broch
Jakobsen, Marianne Antonius
Nielsen, Christian
Grosen, Dorthe
Hartling, Ulla Birgitte
Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
title Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
title_full Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
title_fullStr Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
title_full_unstemmed Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
title_short Association between neutropenia and IgG antineutrophil antibodies in a case of CD40LG deficiency due to two novel mutations
title_sort association between neutropenia and igg antineutrophil antibodies in a case of cd40lg deficiency due to two novel mutations
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044354/
https://www.ncbi.nlm.nih.gov/pubmed/32128179
http://dx.doi.org/10.1002/ccr3.2621
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