Cargando…

Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer

Novel therapies are urgently needed for ovarian cancer, the deadliest gynecologic malignancy. Ovarian cancer has thus far been refractory to immunotherapies that stimulate the host immune system to recognize and kill cancer cells. This may be because of a suppressive tumor immune microenvironment an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moufarrij, Sara, Srivastava, Aneil, Gomez, Stephanie, Hadley, Melissa, Palmer, Erica, Austin, Paul Tran, Chisholm, Sarah, Diab, Noor, Roche, Kyle, Yu, Angela, Li, Jing, Zhu, Wenge, Lopez-Acevedo, Micael, Villagra, Alejandro, Chiappinelli, Katherine B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044433/ https://www.ncbi.nlm.nih.gov/pubmed/32103105 http://dx.doi.org/10.1038/s41598-020-60409-4

Ejemplares similares

Author Correction: Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer
por: Moufarrij, Sara, et al.
Publicado: (2021)

Epigenetic therapy for ovarian cancer: promise and progress
por: Moufarrij, Sara, et al.
Publicado: (2019)

Immunoepigenetics Combination Therapies: An Overview of the Role of HDACs in Cancer Immunotherapy
por: Banik, Debarati, et al.
Publicado: (2019)

Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
por: Gomez, Stephanie, et al.
Publicado: (2022)

The Role of DNMT and HDACs in the Fetal Programming of Hypertension by Glucocorticoids
por: Lamothe, J., et al.
Publicado: (2020)

Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells
por: Ali Khan, Munawwar, et al.
Publicado: (2015)

Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells
por: Knox, Tessa, et al.
Publicado: (2019)

HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications
por: Harada, Takeshi, et al.
Publicado: (2017)

Author Correction: Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells
por: Knox, Tessa, et al.
Publicado: (2019)

Tartrazine Modifies the Activity of DNMT and HDAC Genes—Is This a Link between Cancer and Neurological Disorders?
por: Zand, Afshin, et al.
Publicado: (2023)

The Potential Role of Regulatory Genes (DNMT3A, HDAC5, and HDAC9) in Antipsychotic Treatment Response in South African Schizophrenia Patients
por: O’Connell, Kevin Sean, et al.
Publicado: (2019)

Inhibition of HDAC1 and DNMT1 Modulate RGS10 Expression and Decrease Ovarian Cancer Chemoresistance
por: Cacan, Ercan, et al.
Publicado: (2014)

DNMT and HDAC inhibition induces immunogenic neoantigens from human endogenous retroviral element-derived transcripts
por: Goyal, Ashish, et al.
Publicado: (2023)

Fruit Extract, Rich in Polyphenols and Flavonoids, Modifies the Expression of DNMT and HDAC Genes Involved in Epigenetic Processes
por: Nowrasteh, Ghodratollah, et al.
Publicado: (2023)

Editorial: Genetic and Epigenetic Control of Immune Responses
por: Noonepalle, Satish kumar R., et al.
Publicado: (2021)

HDAC/IKK inhibition therapies in solid tumors
por: Vancurova, Ivana, et al.
Publicado: (2017)

Targeting HDACs in Pancreatic Neuroendocrine Tumor Models
por: Schmitz, Rosa Lynn, et al.
Publicado: (2021)

DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
por: Kerdivel, Gwenneg, et al.
Publicado: (2023)

DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis
por: Shin, Yonghwan, et al.
Publicado: (2019)

8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1
por: Zhang, Qiting, et al.
Publicado: (2021)

A catalytic dependent role for DNMT3B in tumor suppression
por: Li, Haitao, et al.
Publicado: (2021)

Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity
por: Chen, Xiufei, et al.
Publicado: (2022)

Effect of Zebularine in Comparison to and in Combination with Trichostatin A on CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2), DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3) and Class II HDACs (HDACs 4, 5, 6) Gene Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LS 174T Cell Line
por: Sanaei, Masumeh, et al.
Publicado: (2020)

Epigenetics in Brain Tumors: HDACs Take Center Stage
por: Eyüpoglu, Ilker Y., et al.
Publicado: (2016)

HDAC-an important target for improving tumor radiotherapy resistance
por: Ling, Rui, et al.
Publicado: (2023)

Effects of DNMT1 and HDAC Inhibitors on Gene-Specific Methylation Reprogramming during Porcine Somatic Cell Nuclear Transfer
por: Xu, Weihua, et al.
Publicado: (2013)

Low-dose-rate radiation exposure leads to testicular damage with decreases in DNMT1 and HDAC1 in the murine testis
por: Gong, Eun Ji, et al.
Publicado: (2014)

DNMT1 and HDAC2 Cooperate to Facilitate Aberrant Promoter Methylation in Inorganic Phosphate-Induced Endothelial-Mesenchymal Transition
por: Tan, Xiaoying, et al.
Publicado: (2016)

HOXA10 promotion of HDAC1 underpins the development of lung adenocarcinoma through the DNMT1-KLF4 axis
por: Ma, Tiangang, et al.
Publicado: (2021)

P480: DNMT AND HDAC INHIBITION INDUCES IMMUNOGENIC NEOANTIGENS FROM HUMAN ENDOGENOUS RETROVIRAL ELEMENT-DERIVED TRANSCRIPTS
por: Goyal, Ashish, et al.
Publicado: (2023)

Black Raspberry-Derived Anthocyanins Demethylate Tumor Suppressor Genes Through the Inhibition of DNMT1 and DNMT3B in Colon Cancer Cells
por: Wang, Li-Shu, et al.
Publicado: (2013)

Effects of prenatal Poly I:C exposure on global histone deacetylase (HDAC) and DNA methyltransferase (DNMT) activity in the mouse brain
por: Pujol Lopez, Yara, et al.
Publicado: (2016)

HDAC Inhibitors: Dissecting Mechanisms of Action to Counter Tumor Heterogeneity
por: Karagiannis, Dimitris, et al.
Publicado: (2021)

HDAC2 links ubiquitination to tumor suppression in synovial sarcoma
por: Cooley, Christina, et al.
Publicado: (2021)

Specific inhibition of one DNMT1-including complex influences tumor initiation and progression
por: Cheray, Mathilde, et al.
Publicado: (2013)

A Nanoradiomics Approach for Differentiation of Tumors Based on Tumor-Associated Macrophage Burden
por: Starosolski, Zbigniew, et al.
Publicado: (2021)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
por: Van Emburgh, Beth O., et al.
Publicado: (2011)

Separate and Combined Effects of DNMT and HDAC Inhibitors in Treating Human Multi-Drug Resistant Osteosarcoma HosDXR150 Cell Line
por: Capobianco, Enrico, et al.
Publicado: (2014)

Therapeutic Targeting of Tumor Cells and Tumor Immune Microenvironment Vulnerabilities
por: Kalyanaraman, Balaraman, et al.
Publicado: (2022)

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
por: Liao, Jing, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g03hhjr7gf88hon5lkrhs9o7b9