Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1

Ric-8A is a cytosolic Guanine Nucleotide exchange Factor (GEF) that activates heterotrimeric G protein alpha subunits (Gα) and serves as an essential Gα chaperone. Mechanisms by which Ric-8A catalyzes these activities, which are stimulated by Casein Kinase II phosphorylation, are unknown. We report...

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Detalles Bibliográficos
Autores principales: McClelland, Levi J., Zhang, Kaiming, Mou, Tung-Chung, Johnston, Jake, Yates-Hansen, Cindee, Li, Shanshan, Thomas, Celestine J., Doukov, Tzanko I., Triest, Sarah, Wohlkonig, Alexandre, Tall, Gregory G., Steyaert, Jan, Chiu, Wah, Sprang, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044438/
https://www.ncbi.nlm.nih.gov/pubmed/32103024
http://dx.doi.org/10.1038/s41467-020-14943-4

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