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The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome
OBJECTIVE: We present an exemplar patient, illustrating utility of the sural-sparing pattern in diagnosis of Guillain-Barré Syndrome (GBS). We then present data that sheds light on the pathophysiology of sural-sparing. METHOD AND RESULTS: We describe a case of complex ophthalmoplegia that exemplifie...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044466/ https://www.ncbi.nlm.nih.gov/pubmed/32140628 http://dx.doi.org/10.1016/j.cnp.2019.12.002 |
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author | Umapathi, Thirugnanam Koh, Jasmine S. Cheng, Y.J. Goh, Eunice J.H. Lim, Christen S.J. |
author_facet | Umapathi, Thirugnanam Koh, Jasmine S. Cheng, Y.J. Goh, Eunice J.H. Lim, Christen S.J. |
author_sort | Umapathi, Thirugnanam |
collection | PubMed |
description | OBJECTIVE: We present an exemplar patient, illustrating utility of the sural-sparing pattern in diagnosis of Guillain-Barré Syndrome (GBS). We then present data that sheds light on the pathophysiology of sural-sparing. METHOD AND RESULTS: We describe a case of complex ophthalmoplegia that exemplifies the challenge of diagnosing regional subtypes of Guillain-Barré Syndrome, and the value of scrutinizing sensory nerve action potentials for the sural-sparing pattern. We also demonstrate, in a series of GBS patients, how serial nerve conduction studies can reveal “covert” sural-sparing in patients without sural-sparing on the initial study. Finally, by studying the median and radial sensory nerve action potentials at digit I in GBS patients, we demonstrate that the likely pathology of sural-sparing is related to the predilection of median nerve for subclinical entrapment; where the blood-nerve barrier is deficient and therefore more exposed to the immunopathology of GBS. CONCLUSION: Incorporating sural-sparing would improve the specificity of GBS electrodiagnosis; especially in difficult to diagnose regional subtypes of GBS. |
format | Online Article Text |
id | pubmed-7044466 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-70444662020-03-05 The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome Umapathi, Thirugnanam Koh, Jasmine S. Cheng, Y.J. Goh, Eunice J.H. Lim, Christen S.J. Clin Neurophysiol Pract Clinical and Research Article OBJECTIVE: We present an exemplar patient, illustrating utility of the sural-sparing pattern in diagnosis of Guillain-Barré Syndrome (GBS). We then present data that sheds light on the pathophysiology of sural-sparing. METHOD AND RESULTS: We describe a case of complex ophthalmoplegia that exemplifies the challenge of diagnosing regional subtypes of Guillain-Barré Syndrome, and the value of scrutinizing sensory nerve action potentials for the sural-sparing pattern. We also demonstrate, in a series of GBS patients, how serial nerve conduction studies can reveal “covert” sural-sparing in patients without sural-sparing on the initial study. Finally, by studying the median and radial sensory nerve action potentials at digit I in GBS patients, we demonstrate that the likely pathology of sural-sparing is related to the predilection of median nerve for subclinical entrapment; where the blood-nerve barrier is deficient and therefore more exposed to the immunopathology of GBS. CONCLUSION: Incorporating sural-sparing would improve the specificity of GBS electrodiagnosis; especially in difficult to diagnose regional subtypes of GBS. Elsevier 2020-02-07 /pmc/articles/PMC7044466/ /pubmed/32140628 http://dx.doi.org/10.1016/j.cnp.2019.12.002 Text en © 2020 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical and Research Article Umapathi, Thirugnanam Koh, Jasmine S. Cheng, Y.J. Goh, Eunice J.H. Lim, Christen S.J. The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome |
title | The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome |
title_full | The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome |
title_fullStr | The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome |
title_full_unstemmed | The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome |
title_short | The utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of Guillain-Barré Syndrome |
title_sort | utility of sural-sparing pattern in the electrodiagnosis of regional subtypes of guillain-barré syndrome |
topic | Clinical and Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044466/ https://www.ncbi.nlm.nih.gov/pubmed/32140628 http://dx.doi.org/10.1016/j.cnp.2019.12.002 |
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