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Copeptin levels in patients with coronary artery ectasia

BACKGROUND AND AIMS: The etiology and pathophysiology of coronary artery ectasia (CAE) has not been fully elucidated. A rapid rise in plasma copeptin has been observed in cardiovascular diseases, stroke, sepsis, and shock. This increase has diagnostic and prognostic value. The aim of this study was...

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Autores principales: Yavcin, Ozkan, Askin, Lutfu, Seçen, Ozlem, Turkmen, Serdar, Akturk, Erdal, Tanriverdi, Okan, Necati Dagli, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044535/
https://www.ncbi.nlm.nih.gov/pubmed/32148915
http://dx.doi.org/10.1556/1646.11.2019.08
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author Yavcin, Ozkan
Askin, Lutfu
Seçen, Ozlem
Turkmen, Serdar
Akturk, Erdal
Tanriverdi, Okan
Necati Dagli, Mustafa
author_facet Yavcin, Ozkan
Askin, Lutfu
Seçen, Ozlem
Turkmen, Serdar
Akturk, Erdal
Tanriverdi, Okan
Necati Dagli, Mustafa
author_sort Yavcin, Ozkan
collection PubMed
description BACKGROUND AND AIMS: The etiology and pathophysiology of coronary artery ectasia (CAE) has not been fully elucidated. A rapid rise in plasma copeptin has been observed in cardiovascular diseases, stroke, sepsis, and shock. This increase has diagnostic and prognostic value. The aim of this study was to investigate whether copeptin has a relationship with CAE. METHODS: This observational prospective study was carried out between October 2012 and March 2013 in the cardiology catheter laboratory with the inclusion of 44 subjects with a diagnosis of CAE and 44 age- and gender-matched individuals with normal coronary arteries. Blood samples obtained from the patients were stored at −70 °C until analysis and copeptin levels in sera were measured by ELISA. RESULTS: This study comprised 88 study participants, among whom 44 were patients meeting ectasia criteria [mean age: 58.0 ± 11.5 years; 59% (n = 26) male], and 44 were control subjects with angiographically normal coronary anatomy [mean age: 49.2 ± 10.1 years; 30% (n = 13) male]. Copeptin levels were similar between the groups (p > 0.05). In addition, there was no correlation between copeptin levels and CAE. CONCLUSION: In this study, it is examined that copeptin levels were not elevated in CAE patients.
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spelling pubmed-70445352020-03-06 Copeptin levels in patients with coronary artery ectasia Yavcin, Ozkan Askin, Lutfu Seçen, Ozlem Turkmen, Serdar Akturk, Erdal Tanriverdi, Okan Necati Dagli, Mustafa Interv Med Appl Sci Original Paper BACKGROUND AND AIMS: The etiology and pathophysiology of coronary artery ectasia (CAE) has not been fully elucidated. A rapid rise in plasma copeptin has been observed in cardiovascular diseases, stroke, sepsis, and shock. This increase has diagnostic and prognostic value. The aim of this study was to investigate whether copeptin has a relationship with CAE. METHODS: This observational prospective study was carried out between October 2012 and March 2013 in the cardiology catheter laboratory with the inclusion of 44 subjects with a diagnosis of CAE and 44 age- and gender-matched individuals with normal coronary arteries. Blood samples obtained from the patients were stored at −70 °C until analysis and copeptin levels in sera were measured by ELISA. RESULTS: This study comprised 88 study participants, among whom 44 were patients meeting ectasia criteria [mean age: 58.0 ± 11.5 years; 59% (n = 26) male], and 44 were control subjects with angiographically normal coronary anatomy [mean age: 49.2 ± 10.1 years; 30% (n = 13) male]. Copeptin levels were similar between the groups (p > 0.05). In addition, there was no correlation between copeptin levels and CAE. CONCLUSION: In this study, it is examined that copeptin levels were not elevated in CAE patients. Akadémiai Kiadó 2019-05-22 2019-06 /pmc/articles/PMC7044535/ /pubmed/32148915 http://dx.doi.org/10.1556/1646.11.2019.08 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.
spellingShingle Original Paper
Yavcin, Ozkan
Askin, Lutfu
Seçen, Ozlem
Turkmen, Serdar
Akturk, Erdal
Tanriverdi, Okan
Necati Dagli, Mustafa
Copeptin levels in patients with coronary artery ectasia
title Copeptin levels in patients with coronary artery ectasia
title_full Copeptin levels in patients with coronary artery ectasia
title_fullStr Copeptin levels in patients with coronary artery ectasia
title_full_unstemmed Copeptin levels in patients with coronary artery ectasia
title_short Copeptin levels in patients with coronary artery ectasia
title_sort copeptin levels in patients with coronary artery ectasia
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044535/
https://www.ncbi.nlm.nih.gov/pubmed/32148915
http://dx.doi.org/10.1556/1646.11.2019.08
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