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Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls

BACKGROUND: Current evidence indicates that vascular calcification plays an essential role in the development of cardiovascular diseases in end-stage renal disease (ESRD) patients. Arterial stiffness is a marker of increased cardiovascular risk in various populations. The aim of this study is to eva...

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Autores principales: Kalçık, Macit, Yetim, Mucahit, Doğan, Tolga, Doğan, İbrahim, Eser, Barış, Bekar, Lütfü, Çelik, Oğuzhan, Karavelioğlu, Yusuf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Akadémiai Kiadó 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044540/
https://www.ncbi.nlm.nih.gov/pubmed/32148909
http://dx.doi.org/10.1556/1646.11.2019.09
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author Kalçık, Macit
Yetim, Mucahit
Doğan, Tolga
Doğan, İbrahim
Eser, Barış
Bekar, Lütfü
Çelik, Oğuzhan
Karavelioğlu, Yusuf
author_facet Kalçık, Macit
Yetim, Mucahit
Doğan, Tolga
Doğan, İbrahim
Eser, Barış
Bekar, Lütfü
Çelik, Oğuzhan
Karavelioğlu, Yusuf
author_sort Kalçık, Macit
collection PubMed
description BACKGROUND: Current evidence indicates that vascular calcification plays an essential role in the development of cardiovascular diseases in end-stage renal disease (ESRD) patients. Arterial stiffness is a marker of increased cardiovascular risk in various populations. The aim of this study is to evaluate the elastic properties of ascending aorta in patients with ESRD. METHODS: This single-center study enrolled 96 patients (45 females, age: 57.2 ± 12.8 years) with ESRD and 96 healthy controls (52 females, age: 55.3 ± 10.1 years). Aortic pressures and aortic elastic parameters including aortic strain, aortic distensibility, aortic stiffness index, and aortic compliance were calculated using accepted formulae. RESULTS: The hemodynamic parameters including aortic pulse pressure, aortic mean pressure, aortic fractional pulse pressure, and aortic pulsatility index were significantly higher in patients with ESRD. Systolic and diastolic aortic diameters were similar between the groups. However, pulsatile aortic diameter change, aortic strain, aortic distensibility, and aortic compliance were significantly lower, whereas aortic stiffness index was significantly higher in ESRD group. CONCLUSIONS: The results demonstrated that a significant difference was present in terms of aortic blood pressures between patients with ESRD and controls. In addition, the elastic properties of ascending aorta were decreased in patients with ESRD.
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spelling pubmed-70445402020-03-06 Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls Kalçık, Macit Yetim, Mucahit Doğan, Tolga Doğan, İbrahim Eser, Barış Bekar, Lütfü Çelik, Oğuzhan Karavelioğlu, Yusuf Interv Med Appl Sci Original Paper BACKGROUND: Current evidence indicates that vascular calcification plays an essential role in the development of cardiovascular diseases in end-stage renal disease (ESRD) patients. Arterial stiffness is a marker of increased cardiovascular risk in various populations. The aim of this study is to evaluate the elastic properties of ascending aorta in patients with ESRD. METHODS: This single-center study enrolled 96 patients (45 females, age: 57.2 ± 12.8 years) with ESRD and 96 healthy controls (52 females, age: 55.3 ± 10.1 years). Aortic pressures and aortic elastic parameters including aortic strain, aortic distensibility, aortic stiffness index, and aortic compliance were calculated using accepted formulae. RESULTS: The hemodynamic parameters including aortic pulse pressure, aortic mean pressure, aortic fractional pulse pressure, and aortic pulsatility index were significantly higher in patients with ESRD. Systolic and diastolic aortic diameters were similar between the groups. However, pulsatile aortic diameter change, aortic strain, aortic distensibility, and aortic compliance were significantly lower, whereas aortic stiffness index was significantly higher in ESRD group. CONCLUSIONS: The results demonstrated that a significant difference was present in terms of aortic blood pressures between patients with ESRD and controls. In addition, the elastic properties of ascending aorta were decreased in patients with ESRD. Akadémiai Kiadó 2019-05-22 2019-06 /pmc/articles/PMC7044540/ /pubmed/32148909 http://dx.doi.org/10.1556/1646.11.2019.09 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium for non-commercial purposes, provided the original author and source are credited, a link to the CC License is provided, and changes – if any – are indicated.
spellingShingle Original Paper
Kalçık, Macit
Yetim, Mucahit
Doğan, Tolga
Doğan, İbrahim
Eser, Barış
Bekar, Lütfü
Çelik, Oğuzhan
Karavelioğlu, Yusuf
Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
title Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
title_full Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
title_fullStr Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
title_full_unstemmed Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
title_short Comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
title_sort comparison of aortic pressures and aortic elastic properties between patients with end-stage renal disease and healthy controls
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044540/
https://www.ncbi.nlm.nih.gov/pubmed/32148909
http://dx.doi.org/10.1556/1646.11.2019.09
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