CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis

BACKGROUND: Intervertebral disc degeneration (IDD) is a major contributor to lower back pain, however, the molecular and pathogenetic mechanisms underlying IDD are poorly understood. As a high-risk factor for IDD, compression stress was reported to induce apoptosis of nucleus pulposus (NP) cells and...

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Detalles Bibliográficos
Autores principales: Xiang, Qian, Kang, Liang, Wang, Juntan, Liao, Zhiwei, Song, Yu, Zhao, Kangcheng, Wang, Kun, Yang, Cao, Zhang, Yukun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044714/
https://www.ncbi.nlm.nih.gov/pubmed/32114390
http://dx.doi.org/10.1016/j.ebiom.2020.102679

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