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Bone health in bipolar disorder: a study protocol for a case–control study in Australia
INTRODUCTION: Little is known about the bone health of adults with bipolar disorder, aside from evidence purporting bone deficits among individuals with other mental illnesses, or those taking medications commonly used in bipolar disorder. In this paper, we present the methodology of a case–control...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044863/ https://www.ncbi.nlm.nih.gov/pubmed/32051309 http://dx.doi.org/10.1136/bmjopen-2019-032821 |
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author | Williams, Lana J Stuart, Amanda L Berk, Michael Brennan-Olsen, Sharon L Hodge, Jason M Cowdery, Stephanie Chandrasekaran, Vinoomika Pasco, Julie A |
author_facet | Williams, Lana J Stuart, Amanda L Berk, Michael Brennan-Olsen, Sharon L Hodge, Jason M Cowdery, Stephanie Chandrasekaran, Vinoomika Pasco, Julie A |
author_sort | Williams, Lana J |
collection | PubMed |
description | INTRODUCTION: Little is known about the bone health of adults with bipolar disorder, aside from evidence purporting bone deficits among individuals with other mental illnesses, or those taking medications commonly used in bipolar disorder. In this paper, we present the methodology of a case–control study which aims to examine the role of bipolar disorder as a risk factor for bone fragility. METHODS AND ANALYSIS: Men and women with bipolar disorder (~200 cases) will be recruited and compared with participants with no history of bipolar disorder (~1500 controls) from the Geelong Osteoporosis Study. Both cases and controls will be drawn from the Barwon Statistical Division, south-eastern Australia. The Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition is the primary diagnostic instrument, and psychiatric symptomatology will be assessed using validated rating scales. Demographic information and detailed lifestyle data and medical history will be collected via comprehensive questionnaires. Participants will undergo dual energy X-ray absorptiometry scans and other clinical measures to determine bone and body composition. Blood samples will be provided after an overnight fast and stored for batch analysis. ETHICS AND DISSEMINATION: Ethics approval has been granted from Barwon Health Research Ethics Committee. Participation in the study is voluntary. The study findings will be disseminated via peer-reviewed publications, conference presentations and reports to the funding body. |
format | Online Article Text |
id | pubmed-7044863 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-70448632020-03-09 Bone health in bipolar disorder: a study protocol for a case–control study in Australia Williams, Lana J Stuart, Amanda L Berk, Michael Brennan-Olsen, Sharon L Hodge, Jason M Cowdery, Stephanie Chandrasekaran, Vinoomika Pasco, Julie A BMJ Open Mental Health INTRODUCTION: Little is known about the bone health of adults with bipolar disorder, aside from evidence purporting bone deficits among individuals with other mental illnesses, or those taking medications commonly used in bipolar disorder. In this paper, we present the methodology of a case–control study which aims to examine the role of bipolar disorder as a risk factor for bone fragility. METHODS AND ANALYSIS: Men and women with bipolar disorder (~200 cases) will be recruited and compared with participants with no history of bipolar disorder (~1500 controls) from the Geelong Osteoporosis Study. Both cases and controls will be drawn from the Barwon Statistical Division, south-eastern Australia. The Structured Clinical Interview for DSM-IV-TR Research Version, Non-patient edition is the primary diagnostic instrument, and psychiatric symptomatology will be assessed using validated rating scales. Demographic information and detailed lifestyle data and medical history will be collected via comprehensive questionnaires. Participants will undergo dual energy X-ray absorptiometry scans and other clinical measures to determine bone and body composition. Blood samples will be provided after an overnight fast and stored for batch analysis. ETHICS AND DISSEMINATION: Ethics approval has been granted from Barwon Health Research Ethics Committee. Participation in the study is voluntary. The study findings will be disseminated via peer-reviewed publications, conference presentations and reports to the funding body. BMJ Publishing Group 2020-02-12 /pmc/articles/PMC7044863/ /pubmed/32051309 http://dx.doi.org/10.1136/bmjopen-2019-032821 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Mental Health Williams, Lana J Stuart, Amanda L Berk, Michael Brennan-Olsen, Sharon L Hodge, Jason M Cowdery, Stephanie Chandrasekaran, Vinoomika Pasco, Julie A Bone health in bipolar disorder: a study protocol for a case–control study in Australia |
title | Bone health in bipolar disorder: a study protocol for a case–control study in Australia |
title_full | Bone health in bipolar disorder: a study protocol for a case–control study in Australia |
title_fullStr | Bone health in bipolar disorder: a study protocol for a case–control study in Australia |
title_full_unstemmed | Bone health in bipolar disorder: a study protocol for a case–control study in Australia |
title_short | Bone health in bipolar disorder: a study protocol for a case–control study in Australia |
title_sort | bone health in bipolar disorder: a study protocol for a case–control study in australia |
topic | Mental Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044863/ https://www.ncbi.nlm.nih.gov/pubmed/32051309 http://dx.doi.org/10.1136/bmjopen-2019-032821 |
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