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Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis

INTRODUCTION: Polypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations. METHODS AND ANALYSIS: This study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Bur...

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Autores principales: Dearing, Marci Elizabeth, Bowles, Susan, Isenor, Jennifer, Kits, Olga, Kouladjian O'Donnell, Lisa, Neville, Heather, Hilmer, Sarah, Toombs, Kent, Sirois, Caroline, Hajizadeh, Mohammad, Negus, Aprill, Rockwood, Kenneth, Reeve, Emily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044900/
https://www.ncbi.nlm.nih.gov/pubmed/32086361
http://dx.doi.org/10.1136/bmjopen-2019-035656
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author Dearing, Marci Elizabeth
Bowles, Susan
Isenor, Jennifer
Kits, Olga
Kouladjian O'Donnell, Lisa
Neville, Heather
Hilmer, Sarah
Toombs, Kent
Sirois, Caroline
Hajizadeh, Mohammad
Negus, Aprill
Rockwood, Kenneth
Reeve, Emily
author_facet Dearing, Marci Elizabeth
Bowles, Susan
Isenor, Jennifer
Kits, Olga
Kouladjian O'Donnell, Lisa
Neville, Heather
Hilmer, Sarah
Toombs, Kent
Sirois, Caroline
Hajizadeh, Mohammad
Negus, Aprill
Rockwood, Kenneth
Reeve, Emily
author_sort Dearing, Marci Elizabeth
collection PubMed
description INTRODUCTION: Polypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations. METHODS AND ANALYSIS: This study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Burden Index (DBI) Calculator) in four hospital sites in the Canadian province of Nova Scotia. The study aims to enrol 160 participants between the preintervention and intervention groups. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2013 checklist) was used to develop the protocol for this prospective interventional implementation study. A preintervention retrospective control cohort and a multiple case study analysis will also be used to assess the effect of intervention implementation. Statistical analysis will involve change in DBI scores and assessment of clinical outcomes, such as rehospitalisation and mortality using appropriate statistical tests including t-test, χ(2), analysis of variance and unadjusted and adjusted regression methods. ETHICS AND DISSEMINATION: Ethics approval has been granted by the Nova Scotia Health Authority Research Ethics Board. The findings of this study will be published in peer-reviewed journals and presented at local, national and international conferences. TRIAL REGISTRATION NUMBER: NCT03698487.
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spelling pubmed-70449002020-03-09 Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis Dearing, Marci Elizabeth Bowles, Susan Isenor, Jennifer Kits, Olga Kouladjian O'Donnell, Lisa Neville, Heather Hilmer, Sarah Toombs, Kent Sirois, Caroline Hajizadeh, Mohammad Negus, Aprill Rockwood, Kenneth Reeve, Emily BMJ Open Geriatric Medicine INTRODUCTION: Polypharmacy and potentially inappropriate medication use is common in older adults and is associated with adverse outcomes such as falls and hospitalisations. METHODS AND ANALYSIS: This study is a pharmacist-led medication optimisation initiative using an electronic tool (the Drug Burden Index (DBI) Calculator) in four hospital sites in the Canadian province of Nova Scotia. The study aims to enrol 160 participants between the preintervention and intervention groups. The Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2013 checklist) was used to develop the protocol for this prospective interventional implementation study. A preintervention retrospective control cohort and a multiple case study analysis will also be used to assess the effect of intervention implementation. Statistical analysis will involve change in DBI scores and assessment of clinical outcomes, such as rehospitalisation and mortality using appropriate statistical tests including t-test, χ(2), analysis of variance and unadjusted and adjusted regression methods. ETHICS AND DISSEMINATION: Ethics approval has been granted by the Nova Scotia Health Authority Research Ethics Board. The findings of this study will be published in peer-reviewed journals and presented at local, national and international conferences. TRIAL REGISTRATION NUMBER: NCT03698487. BMJ Publishing Group 2020-02-20 /pmc/articles/PMC7044900/ /pubmed/32086361 http://dx.doi.org/10.1136/bmjopen-2019-035656 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Geriatric Medicine
Dearing, Marci Elizabeth
Bowles, Susan
Isenor, Jennifer
Kits, Olga
Kouladjian O'Donnell, Lisa
Neville, Heather
Hilmer, Sarah
Toombs, Kent
Sirois, Caroline
Hajizadeh, Mohammad
Negus, Aprill
Rockwood, Kenneth
Reeve, Emily
Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
title Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
title_full Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
title_fullStr Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
title_full_unstemmed Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
title_short Pharmacist-led intervention to improve medication use in older inpatients using the Drug Burden Index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
title_sort pharmacist-led intervention to improve medication use in older inpatients using the drug burden index: a study protocol for a before/after intervention with a retrospective control group and multiple case analysis
topic Geriatric Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044900/
https://www.ncbi.nlm.nih.gov/pubmed/32086361
http://dx.doi.org/10.1136/bmjopen-2019-035656
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