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Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study
OBJECTIVE: To investigate the prevalence and risk factors of functional decline during hospitalisation and its relationship with postdischarge outcomes in very old patients with acute decompensated heart failure (ADHF) hospitalisation. DESIGN: Prospective cohort study between 1 October 2014 and 31 M...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044905/ https://www.ncbi.nlm.nih.gov/pubmed/32066601 http://dx.doi.org/10.1136/bmjopen-2019-032674 |
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author | Yaku, Hidenori Kato, Takao Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Kato, Masashi Ikeda, Tomoyuki Furukawa, Yutaka Nakagawa, Yoshihisa Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi |
author_facet | Yaku, Hidenori Kato, Takao Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Kato, Masashi Ikeda, Tomoyuki Furukawa, Yutaka Nakagawa, Yoshihisa Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi |
author_sort | Yaku, Hidenori |
collection | PubMed |
description | OBJECTIVE: To investigate the prevalence and risk factors of functional decline during hospitalisation and its relationship with postdischarge outcomes in very old patients with acute decompensated heart failure (ADHF) hospitalisation. DESIGN: Prospective cohort study between 1 October 2014 and 31 March 2016. SETTING: A physician-initiated, multicentre study of consecutive patients admitted for ADHF in 19 hospitals throughout Japan. PARTICIPANTS: Among 3555 patients hospitalised for ADHF (median age (IQR), 80 (71–86) years; 1572 (44%) women), functional decline during the index hospitalisation occurred in 528 patients (15%). PRIMARY AND SECONDARY OUTCOMES: The primary outcome measure was a composite of all-cause death or heart failure (HF) hospitalisation after discharge. The secondary outcome measures were all-cause death, HF hospitalisation, and a composite of all-cause death or all-cause hospitalisation. RESULTS: The independent risk factors for functional decline included age ≥80 years (OR 2.71; 95% CI 2.09 to 3.51), female (OR 1.32; 95% CI 1.05 to 1.67), prior stroke (OR 1.67; 95% CI 1.28 to 2.19), dementia (OR 2.26; 95% CI 1.74 to 2.95), ambulatory before admission (OR 1.74; 95% CI 1.29 to 2.35), elevated body temperature (OR 1.91; 95% CI 1.31 to 2.79), New York Heart Association class III or IV on admission (OR 1.54; 95% CI 1.07 to 2.22), decreased albumin levels (OR 1.76; 95% CI 1.32 to 2.34), hyponatraemia (OR 1.49; 95% CI 1.10 to 2.03) and renal dysfunction (OR 1.55; 95% CI 1.22 to 1.98), after multivariable adjustment. The cumulative 1-year incidence of the primary outcome in the functional decline group was significantly higher than that in the no functional decline group (50% vs 31%, log-rank p<0.001). After adjusting for baseline characteristics, the higher risk of the functional decline group relative to the no functional decline group remained significant (adjusted HR 1.46; 95% CI 1.24 to 1.71; p<0.001). CONCLUSIONS: Independent risk factors of functional decline in very old patients with ADHF were related to both frailty and severity of HF. Functional decline during ADHF hospitalisation was associated with unfavourable postdischarge outcomes. TRIAL REGISTRATION NUMBER: NCT02334891, UMIN000015238. |
format | Online Article Text |
id | pubmed-7044905 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-70449052020-03-09 Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study Yaku, Hidenori Kato, Takao Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Kato, Masashi Ikeda, Tomoyuki Furukawa, Yutaka Nakagawa, Yoshihisa Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi BMJ Open Cardiovascular Medicine OBJECTIVE: To investigate the prevalence and risk factors of functional decline during hospitalisation and its relationship with postdischarge outcomes in very old patients with acute decompensated heart failure (ADHF) hospitalisation. DESIGN: Prospective cohort study between 1 October 2014 and 31 March 2016. SETTING: A physician-initiated, multicentre study of consecutive patients admitted for ADHF in 19 hospitals throughout Japan. PARTICIPANTS: Among 3555 patients hospitalised for ADHF (median age (IQR), 80 (71–86) years; 1572 (44%) women), functional decline during the index hospitalisation occurred in 528 patients (15%). PRIMARY AND SECONDARY OUTCOMES: The primary outcome measure was a composite of all-cause death or heart failure (HF) hospitalisation after discharge. The secondary outcome measures were all-cause death, HF hospitalisation, and a composite of all-cause death or all-cause hospitalisation. RESULTS: The independent risk factors for functional decline included age ≥80 years (OR 2.71; 95% CI 2.09 to 3.51), female (OR 1.32; 95% CI 1.05 to 1.67), prior stroke (OR 1.67; 95% CI 1.28 to 2.19), dementia (OR 2.26; 95% CI 1.74 to 2.95), ambulatory before admission (OR 1.74; 95% CI 1.29 to 2.35), elevated body temperature (OR 1.91; 95% CI 1.31 to 2.79), New York Heart Association class III or IV on admission (OR 1.54; 95% CI 1.07 to 2.22), decreased albumin levels (OR 1.76; 95% CI 1.32 to 2.34), hyponatraemia (OR 1.49; 95% CI 1.10 to 2.03) and renal dysfunction (OR 1.55; 95% CI 1.22 to 1.98), after multivariable adjustment. The cumulative 1-year incidence of the primary outcome in the functional decline group was significantly higher than that in the no functional decline group (50% vs 31%, log-rank p<0.001). After adjusting for baseline characteristics, the higher risk of the functional decline group relative to the no functional decline group remained significant (adjusted HR 1.46; 95% CI 1.24 to 1.71; p<0.001). CONCLUSIONS: Independent risk factors of functional decline in very old patients with ADHF were related to both frailty and severity of HF. Functional decline during ADHF hospitalisation was associated with unfavourable postdischarge outcomes. TRIAL REGISTRATION NUMBER: NCT02334891, UMIN000015238. BMJ Publishing Group 2020-02-16 /pmc/articles/PMC7044905/ /pubmed/32066601 http://dx.doi.org/10.1136/bmjopen-2019-032674 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Cardiovascular Medicine Yaku, Hidenori Kato, Takao Morimoto, Takeshi Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Kato, Masashi Ikeda, Tomoyuki Furukawa, Yutaka Nakagawa, Yoshihisa Sato, Yukihito Kuwahara, Koichiro Kimura, Takeshi Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
title | Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
title_full | Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
title_fullStr | Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
title_full_unstemmed | Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
title_short | Risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
title_sort | risk factors and clinical outcomes of functional decline during hospitalisation in very old patients with acute decompensated heart failure: an observational study |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044905/ https://www.ncbi.nlm.nih.gov/pubmed/32066601 http://dx.doi.org/10.1136/bmjopen-2019-032674 |
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