Asprosin: A Novel Player in Metabolic Diseases

Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is in...

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Autores principales: Yuan, Mingyang, Li, Weidong, Zhu, Yan, Yu, Boyao, Wu, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045041/
https://www.ncbi.nlm.nih.gov/pubmed/32153505
http://dx.doi.org/10.3389/fendo.2020.00064
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author Yuan, Mingyang
Li, Weidong
Zhu, Yan
Yu, Boyao
Wu, Jing
author_facet Yuan, Mingyang
Li, Weidong
Zhu, Yan
Yu, Boyao
Wu, Jing
author_sort Yuan, Mingyang
collection PubMed
description Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is involved in appetite, glucose metabolism, insulin resistance (IR), cell apoptosis, etc. In this review, we will summarize the newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment.
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spelling pubmed-70450412020-03-09 Asprosin: A Novel Player in Metabolic Diseases Yuan, Mingyang Li, Weidong Zhu, Yan Yu, Boyao Wu, Jing Front Endocrinol (Lausanne) Endocrinology Asprosin, a novel glucogenic adipokine, is encoded by two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1) and mainly synthesized and released by white adipose tissue during fasting. Asprosin plays a complex role in the central nervous system (CNS), peripheral tissues, and organs. It is involved in appetite, glucose metabolism, insulin resistance (IR), cell apoptosis, etc. In this review, we will summarize the newly discovered roles of asprosin in metabolic diseases including diabetes, obesity, polycystic ovarian syndrome (PCOS), and cardiovascular disease (CVD), which may contribute to future clinical diagnosis and treatment. Frontiers Media S.A. 2020-02-19 /pmc/articles/PMC7045041/ /pubmed/32153505 http://dx.doi.org/10.3389/fendo.2020.00064 Text en Copyright © 2020 Yuan, Li, Zhu, Yu and Wu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yuan, Mingyang
Li, Weidong
Zhu, Yan
Yu, Boyao
Wu, Jing
Asprosin: A Novel Player in Metabolic Diseases
title Asprosin: A Novel Player in Metabolic Diseases
title_full Asprosin: A Novel Player in Metabolic Diseases
title_fullStr Asprosin: A Novel Player in Metabolic Diseases
title_full_unstemmed Asprosin: A Novel Player in Metabolic Diseases
title_short Asprosin: A Novel Player in Metabolic Diseases
title_sort asprosin: a novel player in metabolic diseases
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045041/
https://www.ncbi.nlm.nih.gov/pubmed/32153505
http://dx.doi.org/10.3389/fendo.2020.00064
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