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Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study

INTRODUCTION: Retrospective studies conducted in psychiatric inpatient wards have shown a relation between the intensity of daylight in patient rooms and the length of stay, pointing to an antidepressant effect of ambient lighting conditions. Light therapy has shown a promising antidepressant effect...

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Autores principales: Volf, Carlo, Aggestrup, Anne Sofie, Petersen, Paul Michael, Dam-Hansen, Carsten, Knorr, Ulla, Petersen, Ema Erkocevic, Engstrøm, Janus, Jakobsen, Janus C, Hansen, Torben Skov, Madsen, Helle Østergaard, Hageman, Ida, Martiny, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045110/
https://www.ncbi.nlm.nih.gov/pubmed/31988225
http://dx.doi.org/10.1136/bmjopen-2019-032233
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author Volf, Carlo
Aggestrup, Anne Sofie
Petersen, Paul Michael
Dam-Hansen, Carsten
Knorr, Ulla
Petersen, Ema Erkocevic
Engstrøm, Janus
Jakobsen, Janus C
Hansen, Torben Skov
Madsen, Helle Østergaard
Hageman, Ida
Martiny, Klaus
author_facet Volf, Carlo
Aggestrup, Anne Sofie
Petersen, Paul Michael
Dam-Hansen, Carsten
Knorr, Ulla
Petersen, Ema Erkocevic
Engstrøm, Janus
Jakobsen, Janus C
Hansen, Torben Skov
Madsen, Helle Østergaard
Hageman, Ida
Martiny, Klaus
author_sort Volf, Carlo
collection PubMed
description INTRODUCTION: Retrospective studies conducted in psychiatric inpatient wards have shown a relation between the intensity of daylight in patient rooms and the length of stay, pointing to an antidepressant effect of ambient lighting conditions. Light therapy has shown a promising antidepressant effect when administered from a light box. The emergence of light-emitting diode (LED) technology has made it possible to build luminaires into rooms and to dynamically mimic the spectral and temporal distribution of daylight. The objective of this study is to investigate the antidepressant efficacy of a newly developed dynamic LED-lighting system installed in an inpatient ward. METHODS AND ANALYSIS: In all, 150 inpatients with a major depressive episode, as part of either a major depressive disorder or as part of a bipolar disorder, will be included. The design is a two-arm 1:1 randomised study with a dynamic LED-lighting arm and a static LED-lighting arm, both as add-on to usual treatment in an inpatient psychiatric ward. The primary outcome is the baseline adjusted score on the 6-item Hamilton Depression Rating Scale at week 3. The secondary outcomes are the mean score on the Suicidal Ideation Attributes Scale at week 3, the mean score on the 17-item Hamilton Depression Rating Scale at week 3 and the mean score on the World Health Organisation Quality of Life-BREF (WHOQOL-BREF) at week 3. The spectral distribution of daylight and LED-light, with a specific focus on light mediated through the intrinsically photosensitive retinal ganglion cells, will be measured. Use of light luminaires will be logged. Assessors of Hamilton Depression Rating Scale scores and data analysts will be blinded for treatment allocation. The study was initiated in May 2019 and will end in December 2021. ETHICS AND DISSEMINATION: No ethical issues are expected. Results will be published in peer-reviewed journals, disseminated electronically and in print and presented at symposia. TRIAL REGISTRATION NUMBER: NCT03821506; Pre-results.
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spelling pubmed-70451102020-03-09 Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study Volf, Carlo Aggestrup, Anne Sofie Petersen, Paul Michael Dam-Hansen, Carsten Knorr, Ulla Petersen, Ema Erkocevic Engstrøm, Janus Jakobsen, Janus C Hansen, Torben Skov Madsen, Helle Østergaard Hageman, Ida Martiny, Klaus BMJ Open Mental Health INTRODUCTION: Retrospective studies conducted in psychiatric inpatient wards have shown a relation between the intensity of daylight in patient rooms and the length of stay, pointing to an antidepressant effect of ambient lighting conditions. Light therapy has shown a promising antidepressant effect when administered from a light box. The emergence of light-emitting diode (LED) technology has made it possible to build luminaires into rooms and to dynamically mimic the spectral and temporal distribution of daylight. The objective of this study is to investigate the antidepressant efficacy of a newly developed dynamic LED-lighting system installed in an inpatient ward. METHODS AND ANALYSIS: In all, 150 inpatients with a major depressive episode, as part of either a major depressive disorder or as part of a bipolar disorder, will be included. The design is a two-arm 1:1 randomised study with a dynamic LED-lighting arm and a static LED-lighting arm, both as add-on to usual treatment in an inpatient psychiatric ward. The primary outcome is the baseline adjusted score on the 6-item Hamilton Depression Rating Scale at week 3. The secondary outcomes are the mean score on the Suicidal Ideation Attributes Scale at week 3, the mean score on the 17-item Hamilton Depression Rating Scale at week 3 and the mean score on the World Health Organisation Quality of Life-BREF (WHOQOL-BREF) at week 3. The spectral distribution of daylight and LED-light, with a specific focus on light mediated through the intrinsically photosensitive retinal ganglion cells, will be measured. Use of light luminaires will be logged. Assessors of Hamilton Depression Rating Scale scores and data analysts will be blinded for treatment allocation. The study was initiated in May 2019 and will end in December 2021. ETHICS AND DISSEMINATION: No ethical issues are expected. Results will be published in peer-reviewed journals, disseminated electronically and in print and presented at symposia. TRIAL REGISTRATION NUMBER: NCT03821506; Pre-results. BMJ Publishing Group 2020-01-26 /pmc/articles/PMC7045110/ /pubmed/31988225 http://dx.doi.org/10.1136/bmjopen-2019-032233 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Mental Health
Volf, Carlo
Aggestrup, Anne Sofie
Petersen, Paul Michael
Dam-Hansen, Carsten
Knorr, Ulla
Petersen, Ema Erkocevic
Engstrøm, Janus
Jakobsen, Janus C
Hansen, Torben Skov
Madsen, Helle Østergaard
Hageman, Ida
Martiny, Klaus
Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
title Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
title_full Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
title_fullStr Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
title_full_unstemmed Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
title_short Dynamic LED-light versus static LED-light for depressed inpatients: study protocol for a randomised clinical study
title_sort dynamic led-light versus static led-light for depressed inpatients: study protocol for a randomised clinical study
topic Mental Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045110/
https://www.ncbi.nlm.nih.gov/pubmed/31988225
http://dx.doi.org/10.1136/bmjopen-2019-032233
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