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Antiviral therapy: Valacyclovir Treatment of Alzheimer’s Disease (VALAD) Trial: protocol for a randomised, double-blind, placebo-controlled, treatment trial
INTRODUCTION: After infection, herpes simplex virus-1 (HSV1) becomes latent in the trigeminal ganglion and can enter the brain via retrograde axonal transport. Recurrent reactivation of HSV1 may lead to neurodegeneration and Alzheimer’s disease (AD) pathology. HSV1 (oral herpes) and HSV2 (genital he...
Autores principales: | Devanand, D P, Andrews, Howard, Kreisl, William C, Razlighi, Qolamreza, Gershon, Anne, Stern, Yaakov, Mintz, Akiva, Wisniewski, Thomas, Acosta, Edward, Pollina, Julianna, Katsikoumbas, Mariasofia, Bell, Karen L, Pelton, Gregory H, Deliyannides, Deborah, Prasad, K M, Huey, Edward D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045215/ https://www.ncbi.nlm.nih.gov/pubmed/32034019 http://dx.doi.org/10.1136/bmjopen-2019-032112 |
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