2D and Heterostructure Nanomaterial Based Strategies for Combating Drug-Resistant Bacteria

[Image: see text] In the last three decades, there has been a huge increase in the number of antibiotic-resistant bacterial strains, which is becoming a serious threat to public health. Since the discovery of new effective antibiotics has dramatically decreased in last ten years, there are huge initiatives to develop new antimicrobial approaches to fight drug-resistant bacterial infections. In the last decade, a new nanoparticle-based tool has emerged to combat deadly bacterial infections, which may overcome the barriers faced by antibiotic resistance. The current mini-review highlights recent reports on two-dimensional (2D) graphene oxide (GO), 2D transition metal dichalcogenides (TMD), 2D MXenes, and 2D heterostructure material-based approaches to tackle bacteria. Notably, we discuss the major design criteria which have been used to develop novel antimicrobial 2D and heterostructure materials to eliminate bacterial infections. Next, details on the various mechanisms underlying antibacterial activity for 2D and heterostructure materials such as physical/mechanical damage, lipid extraction, oxidative stress, and photothermal/photodynamic effects have been discussed. Finally, we highlight the promises, major challenges, and prospects of nanomaterial-based approaches to combat multidrug-resistant bacterial infections.