A new mouse line with reduced GluA2 Q/R site RNA editing exhibits loss of dendritic spines, hippocampal CA1-neuron loss, learning and memory impairments and NMDA receptor-independent seizure vulnerability

Calcium (Ca(2+))-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca(2+)-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nucleic acid, known as the Q/R site. In this study, we exa...

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Detalles Bibliográficos
Autores principales: Konen, Lyndsey M., Wright, Amanda L., Royle, Gordon A., Morris, Gary P., Lau, Benjamin K., Seow, Patrick W., Zinn, Raphael, Milham, Luke T., Vaughan, Christopher W., Vissel, Bryce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045468/
https://www.ncbi.nlm.nih.gov/pubmed/32102661
http://dx.doi.org/10.1186/s13041-020-0545-1

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