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The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression

Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implications on cell death linked to cardiomyopathy, tumorigenesis, and cerebral hemorrhage to name...

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Detalles Bibliográficos
Autores principales: Wu, Yuqing, Zhang, Siwei, Gong, Xiaoxiao, Tam, Samantha, Xiao, Desheng, Liu, Shuang, Tao, Yongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045519/
https://www.ncbi.nlm.nih.gov/pubmed/32103754
http://dx.doi.org/10.1186/s12943-020-01157-x
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author Wu, Yuqing
Zhang, Siwei
Gong, Xiaoxiao
Tam, Samantha
Xiao, Desheng
Liu, Shuang
Tao, Yongguang
author_facet Wu, Yuqing
Zhang, Siwei
Gong, Xiaoxiao
Tam, Samantha
Xiao, Desheng
Liu, Shuang
Tao, Yongguang
author_sort Wu, Yuqing
collection PubMed
description Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implications on cell death linked to cardiomyopathy, tumorigenesis, and cerebral hemorrhage to name a few. Here we summarize current literature on ferroptosis, including organelle dysfunction, signaling transduction pathways, metabolic reprogramming and epigenetic regulators in cancer progression. With regard to organelles, mitochondria-induced cysteine starvation, endoplasmic reticulum-related oxidative stress, lysosome dysfunction and golgi stress-related lipid peroxidation all contribute to induction of ferroptosis. Understanding the underlying mechanism in ferroptosis could provide insight into the treatment of various intractable diseases including cancers.
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spelling pubmed-70455192020-03-03 The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression Wu, Yuqing Zhang, Siwei Gong, Xiaoxiao Tam, Samantha Xiao, Desheng Liu, Shuang Tao, Yongguang Mol Cancer Review Ferroptosis, a novel form of regulated cell death, is different from other types of cell death in morphology, genetics and biochemistry. Increasing evidence indicates that ferroptosis has significant implications on cell death linked to cardiomyopathy, tumorigenesis, and cerebral hemorrhage to name a few. Here we summarize current literature on ferroptosis, including organelle dysfunction, signaling transduction pathways, metabolic reprogramming and epigenetic regulators in cancer progression. With regard to organelles, mitochondria-induced cysteine starvation, endoplasmic reticulum-related oxidative stress, lysosome dysfunction and golgi stress-related lipid peroxidation all contribute to induction of ferroptosis. Understanding the underlying mechanism in ferroptosis could provide insight into the treatment of various intractable diseases including cancers. BioMed Central 2020-02-27 /pmc/articles/PMC7045519/ /pubmed/32103754 http://dx.doi.org/10.1186/s12943-020-01157-x Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Wu, Yuqing
Zhang, Siwei
Gong, Xiaoxiao
Tam, Samantha
Xiao, Desheng
Liu, Shuang
Tao, Yongguang
The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
title The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
title_full The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
title_fullStr The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
title_full_unstemmed The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
title_short The epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
title_sort epigenetic regulators and metabolic changes in ferroptosis-associated cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045519/
https://www.ncbi.nlm.nih.gov/pubmed/32103754
http://dx.doi.org/10.1186/s12943-020-01157-x
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