In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis

Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminon...

Descripción completa

Detalles Bibliográficos
Autores principales: Xin, Qi, Yuan, Miaomiao, Li, Huanping, Song, Xiaoxia, Lu, Jun, Jing, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045558/
https://www.ncbi.nlm.nih.gov/pubmed/32101153
http://dx.doi.org/10.1186/s13567-020-00744-6
_version_ 1783501801367011328
author Xin, Qi
Yuan, Miaomiao
Li, Huanping
Song, Xiaoxia
Lu, Jun
Jing, Tao
author_facet Xin, Qi
Yuan, Miaomiao
Li, Huanping
Song, Xiaoxia
Lu, Jun
Jing, Tao
author_sort Xin, Qi
collection PubMed
description Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis.
format Online
Article
Text
id pubmed-7045558
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-70455582020-03-03 In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis Xin, Qi Yuan, Miaomiao Li, Huanping Song, Xiaoxia Lu, Jun Jing, Tao Vet Res Short Report Echinococcosis is a zoonotic disease caused by cestode species of the genus Echinococcus, which demonstrates considerable medical and veterinary concerns. The development of novel drugs for echinococcosis treatment is urgently needed. In this study, we demonstrated that lonidamine (LND) and 6-aminonicotinamide (6-AN) exhibited considerable in vitro effects against both larval- and adult-stage of E. granulosussensu stricto (s. s.) and E. multilocularis. The combination of LND and 6-AN exhibited a significantly higher activity than the single drug treatment. These results highlight the therapeutic potential of LND, 6-AN and the combination of LND and 6-AN for the treatment of echinococcosis. BioMed Central 2020-02-26 2020 /pmc/articles/PMC7045558/ /pubmed/32101153 http://dx.doi.org/10.1186/s13567-020-00744-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Xin, Qi
Yuan, Miaomiao
Li, Huanping
Song, Xiaoxia
Lu, Jun
Jing, Tao
In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
title In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
title_full In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
title_fullStr In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
title_full_unstemmed In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
title_short In vitro effects of lonidamine and 6-aminonicotinamide against Echinococcus granulosussensu stricto and Echinococcus multilocularis
title_sort in vitro effects of lonidamine and 6-aminonicotinamide against echinococcus granulosussensu stricto and echinococcus multilocularis
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045558/
https://www.ncbi.nlm.nih.gov/pubmed/32101153
http://dx.doi.org/10.1186/s13567-020-00744-6
work_keys_str_mv AT xinqi invitroeffectsoflonidamineand6aminonicotinamideagainstechinococcusgranulosussensustrictoandechinococcusmultilocularis
AT yuanmiaomiao invitroeffectsoflonidamineand6aminonicotinamideagainstechinococcusgranulosussensustrictoandechinococcusmultilocularis
AT lihuanping invitroeffectsoflonidamineand6aminonicotinamideagainstechinococcusgranulosussensustrictoandechinococcusmultilocularis
AT songxiaoxia invitroeffectsoflonidamineand6aminonicotinamideagainstechinococcusgranulosussensustrictoandechinococcusmultilocularis
AT lujun invitroeffectsoflonidamineand6aminonicotinamideagainstechinococcusgranulosussensustrictoandechinococcusmultilocularis
AT jingtao invitroeffectsoflonidamineand6aminonicotinamideagainstechinococcusgranulosussensustrictoandechinococcusmultilocularis

Ejemplares similares