Cargando…
Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial
BACKGROUND: Pelvic organ prolapse (POP) is a common health problem and has significant negative effects on a woman’s quality of life. The transvaginal mesh procedure is a durable reconstructive surgery, but the mesh kits are expensive for underdeveloped countries. Our previous case-series study show...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045611/ https://www.ncbi.nlm.nih.gov/pubmed/32102687 http://dx.doi.org/10.1186/s13063-019-3966-3 |
_version_ | 1783501811606355968 |
---|---|
author | Chen, Juan Yu, Jiajie Morse, Abraham Fünfgeld, Christian Huang, Kuanhui Gong, Jian Tao, Guangshi Wang, Binan Wang, Yuling Jiang, Xiangyang Ababaikeli, Gulina Liu, Peishu Nisier, Hatiguli Zhang, Xiaowei Wang, Ping Sun, Xin Zhu, Lan |
author_facet | Chen, Juan Yu, Jiajie Morse, Abraham Fünfgeld, Christian Huang, Kuanhui Gong, Jian Tao, Guangshi Wang, Binan Wang, Yuling Jiang, Xiangyang Ababaikeli, Gulina Liu, Peishu Nisier, Hatiguli Zhang, Xiaowei Wang, Ping Sun, Xin Zhu, Lan |
author_sort | Chen, Juan |
collection | PubMed |
description | BACKGROUND: Pelvic organ prolapse (POP) is a common health problem and has significant negative effects on a woman’s quality of life. The transvaginal mesh procedure is a durable reconstructive surgery, but the mesh kits are expensive for underdeveloped countries. Our previous case-series study showed that the use of self-cut mesh had a good success rate (91.8% at 1-year follow-up) and low complication rate. This trial is designed to compare a self-cut titanium-coated polypropylene mesh procedure with a mesh kit for the treatment of symptomatic stage III–IV anterior or apical prolapse in terms of efficacy, safety and cost-effectiveness. METHODS: The trial is a randomized controlled multicenter non-inferiority trial. The primary outcome measure is the composite success rate at 1-year follow-up. The secondary outcomes are anatomic outcomes of each vaginal segment (anterior, posterior and apical) using the POP-Q score, subjective improvement of quality of life according to questionnaires, intraoperative parameters, complications and costs. Analysis will be performed according to the intention-to-treat principle. Based on a comparable success rate of 90% and 10% as the margin (β = 0.2 and one-sided α = 0.025), about 312 patients in total from 11 centers will be recruited including 10% dropout. The aims of the research are to demonstrate whether the self-cut mesh procedure is non-inferior to the mesh-kit procedure and to investigate the performance of titanium-coated mesh for vaginal prolapse repair. DISCUSSION: This multicenter non-inferiority trial will evaluate whether the efficacy and safety of self-cut mesh is non-inferior to mesh kits in women with severe symptomatic stage III–IV anterior or apical prolapse. If we are able to show that the self-cut mesh procedure is non-inferior to the mesh-kit procedure in success rates, then the self-cut mesh procedure may be more cost-effective. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03283124. Registered on 17 January 2018. |
format | Online Article Text |
id | pubmed-7045611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70456112020-03-03 Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial Chen, Juan Yu, Jiajie Morse, Abraham Fünfgeld, Christian Huang, Kuanhui Gong, Jian Tao, Guangshi Wang, Binan Wang, Yuling Jiang, Xiangyang Ababaikeli, Gulina Liu, Peishu Nisier, Hatiguli Zhang, Xiaowei Wang, Ping Sun, Xin Zhu, Lan Trials Study Protocol BACKGROUND: Pelvic organ prolapse (POP) is a common health problem and has significant negative effects on a woman’s quality of life. The transvaginal mesh procedure is a durable reconstructive surgery, but the mesh kits are expensive for underdeveloped countries. Our previous case-series study showed that the use of self-cut mesh had a good success rate (91.8% at 1-year follow-up) and low complication rate. This trial is designed to compare a self-cut titanium-coated polypropylene mesh procedure with a mesh kit for the treatment of symptomatic stage III–IV anterior or apical prolapse in terms of efficacy, safety and cost-effectiveness. METHODS: The trial is a randomized controlled multicenter non-inferiority trial. The primary outcome measure is the composite success rate at 1-year follow-up. The secondary outcomes are anatomic outcomes of each vaginal segment (anterior, posterior and apical) using the POP-Q score, subjective improvement of quality of life according to questionnaires, intraoperative parameters, complications and costs. Analysis will be performed according to the intention-to-treat principle. Based on a comparable success rate of 90% and 10% as the margin (β = 0.2 and one-sided α = 0.025), about 312 patients in total from 11 centers will be recruited including 10% dropout. The aims of the research are to demonstrate whether the self-cut mesh procedure is non-inferior to the mesh-kit procedure and to investigate the performance of titanium-coated mesh for vaginal prolapse repair. DISCUSSION: This multicenter non-inferiority trial will evaluate whether the efficacy and safety of self-cut mesh is non-inferior to mesh kits in women with severe symptomatic stage III–IV anterior or apical prolapse. If we are able to show that the self-cut mesh procedure is non-inferior to the mesh-kit procedure in success rates, then the self-cut mesh procedure may be more cost-effective. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03283124. Registered on 17 January 2018. BioMed Central 2020-02-26 /pmc/articles/PMC7045611/ /pubmed/32102687 http://dx.doi.org/10.1186/s13063-019-3966-3 Text en © The Author(s). 2020 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Study Protocol Chen, Juan Yu, Jiajie Morse, Abraham Fünfgeld, Christian Huang, Kuanhui Gong, Jian Tao, Guangshi Wang, Binan Wang, Yuling Jiang, Xiangyang Ababaikeli, Gulina Liu, Peishu Nisier, Hatiguli Zhang, Xiaowei Wang, Ping Sun, Xin Zhu, Lan Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
title | Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
title_full | Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
title_fullStr | Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
title_full_unstemmed | Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
title_short | Self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
title_sort | self-cut titanium-coated polypropylene mesh versus pre-cut mesh-kit for transvaginal treatment of severe pelvic organ prolapse: study protocol for a multicenter non-inferiority trial |
topic | Study Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045611/ https://www.ncbi.nlm.nih.gov/pubmed/32102687 http://dx.doi.org/10.1186/s13063-019-3966-3 |
work_keys_str_mv | AT chenjuan selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT yujiajie selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT morseabraham selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT funfgeldchristian selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT huangkuanhui selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT gongjian selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT taoguangshi selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT wangbinan selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT wangyuling selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT jiangxiangyang selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT ababaikeligulina selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT liupeishu selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT nisierhatiguli selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT zhangxiaowei selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT wangping selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT sunxin selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial AT zhulan selfcuttitaniumcoatedpolypropylenemeshversusprecutmeshkitfortransvaginaltreatmentofseverepelvicorganprolapsestudyprotocolforamulticenternoninferioritytrial |