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Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia
BACKGROUND: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from p...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045640/ https://www.ncbi.nlm.nih.gov/pubmed/32102663 http://dx.doi.org/10.1186/s12882-020-01727-7 |
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author | Arapović, Adela Vukojević, Katarina Filipović, Natalija Glavina Durdov, Merica Ljubanović-Galešić, Danica Saraga-Babić, Mirna Prgomet, Sandra Simičić Majce, Ana Belavić, Anja Borić Škaro, Dijana Ljutić, Dragan Saraga, Marijan |
author_facet | Arapović, Adela Vukojević, Katarina Filipović, Natalija Glavina Durdov, Merica Ljubanović-Galešić, Danica Saraga-Babić, Mirna Prgomet, Sandra Simičić Majce, Ana Belavić, Anja Borić Škaro, Dijana Ljutić, Dragan Saraga, Marijan |
author_sort | Arapović, Adela |
collection | PubMed |
description | BACKGROUND: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia. METHODS: Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Kidney allograft biopsy, and re-biopsy were excluded. The biopsy sections were examined under light microscopy, immunofluorescence and electron microscopy. The data was reviewed to determine the pathohistological spectrum and clinicopathologic correlations. We retrospectively analyzed kidney biopsy data from 2008 to 2017 and compared them to that between 1995 and 2005. RESULTS: The mean age of patients was 9.84 ± 5.4 years. Male:female ratio was 1.2:1. The main indications for biopsy were pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%). The most common pathohistological findings were IgA nephropathy (IgAN, 24.1%), minimal change disease (MCD, 16.7%), Henoch-Schönlein purpura glomerulonephritis (HSPN, 14.8%), Alport syndrome and focal segmental glomerulosclerosis (AS and FSGS, 11.1% each), tubulointerstitial nephritis and membranous glomerulopathy (TIN and MGN, 3.7% each), while other cases were diagnosed rarely. CONCLUSIONS: Changes in epidemiology of renal diseases in children between the analyzed periods showed an increasing trend of IgAN, MCD, HSPN, AS and FSGS, while mesangioproliferative glomerulonephritis (MesPGN) and endoproliferative glomerulonephritis (EDGN) showed a decreasing trend that can be explained with the new pathohistological classification. |
format | Online Article Text |
id | pubmed-7045640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-70456402020-03-03 Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia Arapović, Adela Vukojević, Katarina Filipović, Natalija Glavina Durdov, Merica Ljubanović-Galešić, Danica Saraga-Babić, Mirna Prgomet, Sandra Simičić Majce, Ana Belavić, Anja Borić Škaro, Dijana Ljutić, Dragan Saraga, Marijan BMC Nephrol Research Article BACKGROUND: Information about renal diseases in children is available from national registries of renal biopsies. Aim of the study was to compare the clinical presentation of glomerular diseases and tubulointerstitial space diseases with pathohistological diagnosis of indicated renal biopsies from pediatric population in the Croatian region of Dalmatia. METHODS: Out of 231 pediatric patients with suspected glomerular and tubulointerstitial diseases, 54 underwent ultrasound-guided renal biopsy at University Hospital of Split. Kidney allograft biopsy, and re-biopsy were excluded. The biopsy sections were examined under light microscopy, immunofluorescence and electron microscopy. The data was reviewed to determine the pathohistological spectrum and clinicopathologic correlations. We retrospectively analyzed kidney biopsy data from 2008 to 2017 and compared them to that between 1995 and 2005. RESULTS: The mean age of patients was 9.84 ± 5.4 years. Male:female ratio was 1.2:1. The main indications for biopsy were pure nephrotic syndrome without hematuria (25.9%), non-nephrotic proteinuria with haematuria (22.2%), nephritic syndrome with nephrotic proteinuria (18.5%), and isolated hematuria (16.7%). The most common pathohistological findings were IgA nephropathy (IgAN, 24.1%), minimal change disease (MCD, 16.7%), Henoch-Schönlein purpura glomerulonephritis (HSPN, 14.8%), Alport syndrome and focal segmental glomerulosclerosis (AS and FSGS, 11.1% each), tubulointerstitial nephritis and membranous glomerulopathy (TIN and MGN, 3.7% each), while other cases were diagnosed rarely. CONCLUSIONS: Changes in epidemiology of renal diseases in children between the analyzed periods showed an increasing trend of IgAN, MCD, HSPN, AS and FSGS, while mesangioproliferative glomerulonephritis (MesPGN) and endoproliferative glomerulonephritis (EDGN) showed a decreasing trend that can be explained with the new pathohistological classification. BioMed Central 2020-02-26 /pmc/articles/PMC7045640/ /pubmed/32102663 http://dx.doi.org/10.1186/s12882-020-01727-7 Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Arapović, Adela Vukojević, Katarina Filipović, Natalija Glavina Durdov, Merica Ljubanović-Galešić, Danica Saraga-Babić, Mirna Prgomet, Sandra Simičić Majce, Ana Belavić, Anja Borić Škaro, Dijana Ljutić, Dragan Saraga, Marijan Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia |
title | Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia |
title_full | Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia |
title_fullStr | Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia |
title_full_unstemmed | Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia |
title_short | Epidemiology of 10-year paediatric renal biopsies in the region of southern Croatia |
title_sort | epidemiology of 10-year paediatric renal biopsies in the region of southern croatia |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045640/ https://www.ncbi.nlm.nih.gov/pubmed/32102663 http://dx.doi.org/10.1186/s12882-020-01727-7 |
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