Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

[Image: see text] The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.

Detalles Bibliográficos
Autores principales: Höfler, Georg T., But, Andrada, Younes, Sabry H. H., Wever, Ron, Paul, Caroline E., Arends, Isabel W. C. E., Hollmann, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045808/
https://www.ncbi.nlm.nih.gov/pubmed/32117647
http://dx.doi.org/10.1021/acssuschemeng.9b07494
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author Höfler, Georg T.
But, Andrada
Younes, Sabry H. H.
Wever, Ron
Paul, Caroline E.
Arends, Isabel W. C. E.
Hollmann, Frank
author_facet Höfler, Georg T.
But, Andrada
Younes, Sabry H. H.
Wever, Ron
Paul, Caroline E.
Arends, Isabel W. C. E.
Hollmann, Frank
author_sort Höfler, Georg T.
collection PubMed
description [Image: see text] The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.
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spelling pubmed-70458082020-02-28 Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale Höfler, Georg T. But, Andrada Younes, Sabry H. H. Wever, Ron Paul, Caroline E. Arends, Isabel W. C. E. Hollmann, Frank ACS Sustain Chem Eng [Image: see text] The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction. American Chemical Society 2020-01-31 2020-02-24 /pmc/articles/PMC7045808/ /pubmed/32117647 http://dx.doi.org/10.1021/acssuschemeng.9b07494 Text en Copyright © 2020 American Chemical Society This is an open access article published under a Creative Commons Non-Commercial No Derivative Works (CC-BY-NC-ND) Attribution License (http://pubs.acs.org/page/policy/authorchoice_ccbyncnd_termsofuse.html) , which permits copying and redistribution of the article, and creation of adaptations, all for non-commercial purposes.
spellingShingle Höfler, Georg T.
But, Andrada
Younes, Sabry H. H.
Wever, Ron
Paul, Caroline E.
Arends, Isabel W. C. E.
Hollmann, Frank
Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
title Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
title_full Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
title_fullStr Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
title_full_unstemmed Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
title_short Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
title_sort chemoenzymatic halocyclization of 4-pentenoic acid at preparative scale
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045808/
https://www.ncbi.nlm.nih.gov/pubmed/32117647
http://dx.doi.org/10.1021/acssuschemeng.9b07494
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