Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017

Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically...

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Autores principales: Guan, Qingtian, Almutairi, Talal S., Alhalouli, Tahani, Pain, Arnab, Alasmari, Faisal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045828/
https://www.ncbi.nlm.nih.gov/pubmed/32091380
http://dx.doi.org/10.3201/eid2603.190661
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author Guan, Qingtian
Almutairi, Talal S.
Alhalouli, Tahani
Pain, Arnab
Alasmari, Faisal
author_facet Guan, Qingtian
Almutairi, Talal S.
Alhalouli, Tahani
Pain, Arnab
Alasmari, Faisal
author_sort Guan, Qingtian
collection PubMed
description Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically observed. Metagenomics sequencing can be used to identify multidrug-resistant M. leprae.
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spelling pubmed-70458282020-03-07 Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017 Guan, Qingtian Almutairi, Talal S. Alhalouli, Tahani Pain, Arnab Alasmari, Faisal Emerg Infect Dis Research Letter Using shotgun metagenomics, we identified an imported case of multidrug-resistant Mycobacterium leprae in a Filipino resident of Saudi Arabia in 2017. We determined the phylogenomic lineage (3K1) and identified mutations in rpoB and rrs corresponding to the multidrug-resistance phenotype clinically observed. Metagenomics sequencing can be used to identify multidrug-resistant M. leprae. Centers for Disease Control and Prevention 2020-03 /pmc/articles/PMC7045828/ /pubmed/32091380 http://dx.doi.org/10.3201/eid2603.190661 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Guan, Qingtian
Almutairi, Talal S.
Alhalouli, Tahani
Pain, Arnab
Alasmari, Faisal
Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
title Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
title_full Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
title_fullStr Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
title_full_unstemmed Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
title_short Metagenomics of Imported Multidrug-Resistant Mycobacterium leprae, Saudi Arabia, 2017
title_sort metagenomics of imported multidrug-resistant mycobacterium leprae, saudi arabia, 2017
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045828/
https://www.ncbi.nlm.nih.gov/pubmed/32091380
http://dx.doi.org/10.3201/eid2603.190661
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