Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors...

Descripción completa

Detalles Bibliográficos
Autores principales: Merker, Matthias, Nikolaevskaya, Elena, Kohl, Thomas A., Molina-Moya, Barbara, Pavlovska, Olha, Brännberg, Patrik, Dudnyk, Andrii, Stokich, Valentyna, Barilar, Ivan, Marynova, Iryna, Filipova, Tetiana, Prat, Cristina, Sjöstedt, Anders, Dominguez, Jose, Rzhepishevska, Olena, Niemann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045844/
https://www.ncbi.nlm.nih.gov/pubmed/32091369
http://dx.doi.org/10.3201/eid2603.190525
Descripción
Sumario:Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine.

Ejemplares similares