Cargando…
Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045844/ https://www.ncbi.nlm.nih.gov/pubmed/32091369 http://dx.doi.org/10.3201/eid2603.190525 |
_version_ | 1783501856315539456 |
---|---|
author | Merker, Matthias Nikolaevskaya, Elena Kohl, Thomas A. Molina-Moya, Barbara Pavlovska, Olha Brännberg, Patrik Dudnyk, Andrii Stokich, Valentyna Barilar, Ivan Marynova, Iryna Filipova, Tetiana Prat, Cristina Sjöstedt, Anders Dominguez, Jose Rzhepishevska, Olena Niemann, Stefan |
author_facet | Merker, Matthias Nikolaevskaya, Elena Kohl, Thomas A. Molina-Moya, Barbara Pavlovska, Olha Brännberg, Patrik Dudnyk, Andrii Stokich, Valentyna Barilar, Ivan Marynova, Iryna Filipova, Tetiana Prat, Cristina Sjöstedt, Anders Dominguez, Jose Rzhepishevska, Olena Niemann, Stefan |
author_sort | Merker, Matthias |
collection | PubMed |
description | Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine. |
format | Online Article Text |
id | pubmed-7045844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-70458442020-03-07 Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 Merker, Matthias Nikolaevskaya, Elena Kohl, Thomas A. Molina-Moya, Barbara Pavlovska, Olha Brännberg, Patrik Dudnyk, Andrii Stokich, Valentyna Barilar, Ivan Marynova, Iryna Filipova, Tetiana Prat, Cristina Sjöstedt, Anders Dominguez, Jose Rzhepishevska, Olena Niemann, Stefan Emerg Infect Dis Research Multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is an emerging threat to TB control in Ukraine, a country with the third highest XDR TB burden globally. We used whole-genome sequencing of a convenience sample to identify bacterial genetic and patient-related factors associated with MDR/XDR TB in this country. MDR/XDR TB was associated with 3 distinct Mycobacterium tuberculosis complex lineage 2 (Beijing) clades, Europe/Russia W148 outbreak, Central Asia outbreak, and Ukraine outbreak, which comprised 68.9% of all MDR/XDR TB strains from southern Ukraine. MDR/XDR TB was also associated with previous treatment for TB and urban residence. The circulation of Beijing outbreak strains harboring broad drug resistance, coupled with constraints in drug supply and limited availability of phenotypic drug susceptibility testing, needs to be considered when new TB management strategies are implemented in Ukraine. Centers for Disease Control and Prevention 2020-03 /pmc/articles/PMC7045844/ /pubmed/32091369 http://dx.doi.org/10.3201/eid2603.190525 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Merker, Matthias Nikolaevskaya, Elena Kohl, Thomas A. Molina-Moya, Barbara Pavlovska, Olha Brännberg, Patrik Dudnyk, Andrii Stokich, Valentyna Barilar, Ivan Marynova, Iryna Filipova, Tetiana Prat, Cristina Sjöstedt, Anders Dominguez, Jose Rzhepishevska, Olena Niemann, Stefan Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 |
title | Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 |
title_full | Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 |
title_fullStr | Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 |
title_full_unstemmed | Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 |
title_short | Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Beijing Clades, Ukraine, 2015 |
title_sort | multidrug- and extensively drug-resistant mycobacterium tuberculosis beijing clades, ukraine, 2015 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045844/ https://www.ncbi.nlm.nih.gov/pubmed/32091369 http://dx.doi.org/10.3201/eid2603.190525 |
work_keys_str_mv | AT merkermatthias multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT nikolaevskayaelena multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT kohlthomasa multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT molinamoyabarbara multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT pavlovskaolha multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT brannbergpatrik multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT dudnykandrii multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT stokichvalentyna multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT barilarivan multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT marynovairyna multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT filipovatetiana multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT pratcristina multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT sjostedtanders multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT dominguezjose multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT rzhepishevskaolena multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 AT niemannstefan multidrugandextensivelydrugresistantmycobacteriumtuberculosisbeijingcladesukraine2015 |