Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

Nontuberculous mycobacteria (NTM) are an emerging cause of infections, including chronic lymphadenitis in children. To identify risk factors for NTM lymphadenitis, particularly complicated disease, we collected epidemiologic, clinical, and microbiological data on 138 cases of NTM lymphadenitis in ch...

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Detalles Bibliográficos
Autores principales: Kuntz, Martin, Kohlfürst, Daniela S., Feiterna-Sperling, Cornelia, Krüger, Renate, Baumann, Ulrich, Buchtala, Laura, Elling, Roland, Grote, Veit, Hübner, Johannes, Hufnagel, Markus, Kaiser-Labusch, Petra, Liese, Johannes, Otto, Eva-Maria, Rose, Markus A., Schneider, Christian, Schuster, Volker, Seidl, Maximilian, Sommerburg, Olaf, Vogel, Markus, von Bernuth, Horst, Weiß, Michael, Zimmermann, Theodor, Nieters, Alexandra, Zenz, Werner, Henneke, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045849/
https://www.ncbi.nlm.nih.gov/pubmed/32091372
http://dx.doi.org/10.3201/eid2603.191388
Descripción
Sumario:Nontuberculous mycobacteria (NTM) are an emerging cause of infections, including chronic lymphadenitis in children. To identify risk factors for NTM lymphadenitis, particularly complicated disease, we collected epidemiologic, clinical, and microbiological data on 138 cases of NTM lymphadenitis in children across 13 centers in Germany and Austria. We assessed lifestyle factors but did not identify specific risk behaviors. We noted that more cases of NTM lymphadenitis occurred during cold months than during warm months. Moreover, we noted female sex and age <5.5 years as potential risk factors. Complete extirpation of the affected lymph node appeared to be the best therapeutic measure. We integrated the study data to develop a simple risk score to predict unfavorable clinical outcomes for NTM lymphadenitis.

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