Is there a link between IL-23/IL-17 and developmental pathways such as the Wnt and Hedgehog pathway?

Recent experimental evidence suggests that IL-23 may induce spondyloarthropathy by acting on entheseal resident “innate-like” T cells. These cells express IL-23R and respond to IL-23 by secreting inflammatory cytokines such as IL-6 and IL-17 as well as IL-22 which acts on osteoblasts and regulates b...

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Detalles Bibliográficos
Autores principales: Stamatis-Liossis, Nicholas, Daoussis, Dimitrios, Drosos, Alexandros, Sakkas, Lazaros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Mediterranean Journal of Rheumatology (MJR) 2017
Materias:
Research Protocols-Proposals
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045931/
https://www.ncbi.nlm.nih.gov/pubmed/32185257
http://dx.doi.org/10.31138/mjr.28.1.59
Descripción
Sumario:Recent experimental evidence suggests that IL-23 may induce spondyloarthropathy by acting on entheseal resident “innate-like” T cells. These cells express IL-23R and respond to IL-23 by secreting inflammatory cytokines such as IL-6 and IL-17 as well as IL-22 which acts on osteoblasts and regulates bone remodeling. Moreover, a large amount of evidence indicates that new bone formation in the form of osteophytes is mainly driven by reactivation of developmental pathways such as the Wnt and the Hedgehog pathway. We hypothesize that IL-23/IL-17 may mediate bone remodeling by affecting the expression of developmental pathways.

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