Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4

Exposure to thalidomide during a critical window of development results in limb defects in humans and non-human primates while mice and rats are refractory to these effects. Thalidomide-induced teratogenicity is dependent on its binding to cereblon (CRBN), the substrate receptor of the Cul4A-DDB1-CR...

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Detalles Bibliográficos
Autores principales: Belair, David G., Lu, Gang, Waller, Laura E., Gustin, Jason A., Collins, Nathaniel D., Kolaja, Kyle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046148/
https://www.ncbi.nlm.nih.gov/pubmed/32071327
http://dx.doi.org/10.1038/s41598-020-59542-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7046148/
https://www.ncbi.nlm.nih.gov/pubmed/32071327
http://dx.doi.org/10.1038/s41598-020-59542-x

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